HSP90AB1 protein (Equus caballus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

HSP90AB1

Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] (730 aa)

Predicted Functional Partners:

AHR

0.998

SUGT1

0.996

AIP

0.995

PTGES3

0.993

AR

0.974

CDC37

0.973

STIP1

0.963

AKT2

0.958

AKT3

0.958

AKT1

0.958

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHR	AIP	ENSECAP00000011365	ENSECAP00000014918	Uncharacterized protein.	Peptidylprolyl isomerase.	0.998
AHR	HSP90AB1	ENSECAP00000011365	ENSECAP00000006887	Uncharacterized protein.	Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...]	0.998
AHR	PTGES3	ENSECAP00000011365	ENSECAP00000011047	Uncharacterized protein.	Prostaglandin E synthase 3.	0.962
AIP	AHR	ENSECAP00000014918	ENSECAP00000011365	Peptidylprolyl isomerase.	Uncharacterized protein.	0.998
AIP	HSP90AB1	ENSECAP00000014918	ENSECAP00000006887	Peptidylprolyl isomerase.	Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...]	0.995
AIP	PTGES3	ENSECAP00000014918	ENSECAP00000011047	Peptidylprolyl isomerase.	Prostaglandin E synthase 3.	0.970
AKT1	AKT2	ENSECAP00000033932	ENSECAP00000006890	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase.	0.929
AKT1	AKT3	ENSECAP00000033932	ENSECAP00000017503	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.902
AKT1	CDC37	ENSECAP00000033932	ENSECAP00000010796	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cell division cycle 37.	0.941
AKT1	HSP90AB1	ENSECAP00000033932	ENSECAP00000006887	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...]	0.958
AKT2	AKT1	ENSECAP00000006890	ENSECAP00000033932	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.929
AKT2	AKT3	ENSECAP00000006890	ENSECAP00000017503	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.903
AKT2	CDC37	ENSECAP00000006890	ENSECAP00000010796	Non-specific serine/threonine protein kinase.	Cell division cycle 37.	0.941
AKT2	HSP90AB1	ENSECAP00000006890	ENSECAP00000006887	Non-specific serine/threonine protein kinase.	Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...]	0.958
AKT3	AKT1	ENSECAP00000017503	ENSECAP00000033932	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.902
AKT3	AKT2	ENSECAP00000017503	ENSECAP00000006890	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase.	0.903
AKT3	CDC37	ENSECAP00000017503	ENSECAP00000010796	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cell division cycle 37.	0.940
AKT3	HSP90AB1	ENSECAP00000017503	ENSECAP00000006887	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...]	0.958
AR	HSP90AB1	ENSECAP00000008070	ENSECAP00000006887	Androgen receptor.	Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...]	0.974
AR	PTGES3	ENSECAP00000008070	ENSECAP00000011047	Androgen receptor.	Prostaglandin E synthase 3.	0.863

page 1 of 3

Server load: low (34%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2023

Credits

Access

Info

About