node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCNA1 | CDC6 | ENSECAP00000017104 | ENSECAP00000007993 | Cyclin A1; Belongs to the cyclin family. | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | 0.998 |
CCNA1 | CDT1 | ENSECAP00000017104 | ENSECAP00000004068 | Cyclin A1; Belongs to the cyclin family. | Chromatin licensing and DNA replication factor 1. | 0.957 |
CCNA1 | MCM3 | ENSECAP00000017104 | ENSECAP00000018348 | Cyclin A1; Belongs to the cyclin family. | DNA helicase; Belongs to the MCM family. | 0.836 |
CCNA1 | MCM6 | ENSECAP00000017104 | ENSECAP00000007191 | Cyclin A1; Belongs to the cyclin family. | DNA helicase; Belongs to the MCM family. | 0.923 |
CCNA1 | MCM7 | ENSECAP00000017104 | ENSECAP00000012777 | Cyclin A1; Belongs to the cyclin family. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.931 |
CCNA1 | ORC1 | ENSECAP00000017104 | ENSECAP00000007647 | Cyclin A1; Belongs to the cyclin family. | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | 0.927 |
CCNA1 | ORC2 | ENSECAP00000017104 | ENSECAP00000007620 | Cyclin A1; Belongs to the cyclin family. | Origin recognition complex subunit 2. | 0.697 |
CCNA1 | ORC3 | ENSECAP00000017104 | ENSECAP00000015918 | Cyclin A1; Belongs to the cyclin family. | Origin recognition complex subunit 3. | 0.583 |
CCNA1 | ORC4 | ENSECAP00000017104 | ENSECAP00000011986 | Cyclin A1; Belongs to the cyclin family. | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. | 0.645 |
CCNA1 | ORC6 | ENSECAP00000017104 | ENSECAP00000005244 | Cyclin A1; Belongs to the cyclin family. | Origin recognition complex subunit 6. | 0.617 |
CDC6 | CCNA1 | ENSECAP00000007993 | ENSECAP00000017104 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Cyclin A1; Belongs to the cyclin family. | 0.998 |
CDC6 | CDT1 | ENSECAP00000007993 | ENSECAP00000004068 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Chromatin licensing and DNA replication factor 1. | 0.999 |
CDC6 | MCM3 | ENSECAP00000007993 | ENSECAP00000018348 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA helicase; Belongs to the MCM family. | 0.998 |
CDC6 | MCM6 | ENSECAP00000007993 | ENSECAP00000007191 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA helicase; Belongs to the MCM family. | 0.999 |
CDC6 | MCM7 | ENSECAP00000007993 | ENSECAP00000012777 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.998 |
CDC6 | ORC1 | ENSECAP00000007993 | ENSECAP00000007647 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | 0.999 |
CDC6 | ORC2 | ENSECAP00000007993 | ENSECAP00000007620 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Origin recognition complex subunit 2. | 0.999 |
CDC6 | ORC3 | ENSECAP00000007993 | ENSECAP00000015918 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Origin recognition complex subunit 3. | 0.999 |
CDC6 | ORC4 | ENSECAP00000007993 | ENSECAP00000011986 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. | 0.999 |
CDC6 | ORC6 | ENSECAP00000007993 | ENSECAP00000005244 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Origin recognition complex subunit 6. | 0.999 |