STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IFNAR1Interferon alpha and beta receptor subunit 1. (561 aa)    
Predicted Functional Partners:
TYK2
Tyrosine-protein kinase.
   
 0.999
IFNAR2
Uncharacterized protein.
   
 0.999
IFNB1
Interferon beta; Has antiviral, antibacterial and anticancer activities.
   
 0.998
JAK1
Tyrosine-protein kinase.
   
 0.998
STAT2
Signal transducer and activator of transcription.
   
 0.995
STAT1
Signal transducer and activator of transcription.
   
 0.993
LOC100147174
Uncharacterized protein.
   
 0.986
IFNG
Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.
     
 0.982
IFNGR1
Interferon gamma receptor 1.
   
 0.980
IFN-ALPHA2
Interferon alpha-2; Produced by macrophages, IFN-alpha have antiviral activities.
   
 0.978
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.