STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ITGB4Integrin beta. (1805 aa)    
Predicted Functional Partners:
ITGA6
Integrin subunit alpha 6; Belongs to the integrin alpha chain family.
   
 0.999
SRC
Tyrosine-protein kinase.
   
 0.979
PXN
Paxillin.
   
 0.979
PTK2
Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.
   
 0.960
TLN1
Talin 1.
   
 0.951
PLEC
Plectin.
  
 0.951
TLN2
Talin 2.
   
 0.950
SGCA
Integrin subunit alpha 3; Belongs to the integrin alpha chain family.
   
 0.948
ACTB
Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.
    
 0.935
ILK
Integrin linked kinase.
    
 0.927
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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