node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CLU | ELSPBP1 | ENSECAP00000005450 | ENSECAP00000009719 | Clusterin alpha chain; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysos [...] | Epididymal sperm binding protein 1. | 0.400 |
CLU | KLK1E2 | ENSECAP00000005450 | ENSECAP00000009529 | Clusterin alpha chain; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysos [...] | Kallikrein-1E2; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin; Belongs to the peptidase S1 family. Kallikrein subfamily. | 0.531 |
CLUL1 | ELSPBP1 | ENSECAP00000019822 | ENSECAP00000009719 | Clusterin; Belongs to the clusterin family. | Epididymal sperm binding protein 1. | 0.476 |
CLUL1 | KLK1E2 | ENSECAP00000019822 | ENSECAP00000009529 | Clusterin; Belongs to the clusterin family. | Kallikrein-1E2; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin; Belongs to the peptidase S1 family. Kallikrein subfamily. | 0.611 |
CRISP2 | ELSPBP1 | ENSECAP00000054102 | ENSECAP00000009719 | Cysteine-rich secretory protein 3. | Epididymal sperm binding protein 1. | 0.550 |
CRISP2 | IZUMO4 | ENSECAP00000054102 | ENSECAP00000055166 | Cysteine-rich secretory protein 3. | IZUMO family member 4. | 0.480 |
CRISP2 | KLK1E2 | ENSECAP00000054102 | ENSECAP00000009529 | Cysteine-rich secretory protein 3. | Kallikrein-1E2; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin; Belongs to the peptidase S1 family. Kallikrein subfamily. | 0.644 |
ELSPBP1 | CLU | ENSECAP00000009719 | ENSECAP00000005450 | Epididymal sperm binding protein 1. | Clusterin alpha chain; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysos [...] | 0.400 |
ELSPBP1 | CLUL1 | ENSECAP00000009719 | ENSECAP00000019822 | Epididymal sperm binding protein 1. | Clusterin; Belongs to the clusterin family. | 0.476 |
ELSPBP1 | CRISP2 | ENSECAP00000009719 | ENSECAP00000054102 | Epididymal sperm binding protein 1. | Cysteine-rich secretory protein 3. | 0.550 |
ELSPBP1 | IZUMO4 | ENSECAP00000009719 | ENSECAP00000055166 | Epididymal sperm binding protein 1. | IZUMO family member 4. | 0.650 |
ELSPBP1 | KLK1E2 | ENSECAP00000009719 | ENSECAP00000009529 | Epididymal sperm binding protein 1. | Kallikrein-1E2; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin; Belongs to the peptidase S1 family. Kallikrein subfamily. | 0.602 |
F7DW27_HORSE | KLK1 | ENSECAP00000012812 | ENSECAP00000018835 | Peptidase S1 domain-containing protein. | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | 0.900 |
F7DW27_HORSE | KLK1E2 | ENSECAP00000012812 | ENSECAP00000009529 | Peptidase S1 domain-containing protein. | Kallikrein-1E2; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin; Belongs to the peptidase S1 family. Kallikrein subfamily. | 0.901 |
F7DW27_HORSE | MET | ENSECAP00000012812 | ENSECAP00000008993 | Peptidase S1 domain-containing protein. | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | 0.501 |
F7DW27_HORSE | TMC4 | ENSECAP00000012812 | ENSECAP00000010666 | Peptidase S1 domain-containing protein. | Transmembrane channel-like protein. | 0.657 |
IZUMO4 | CRISP2 | ENSECAP00000055166 | ENSECAP00000054102 | IZUMO family member 4. | Cysteine-rich secretory protein 3. | 0.480 |
IZUMO4 | ELSPBP1 | ENSECAP00000055166 | ENSECAP00000009719 | IZUMO family member 4. | Epididymal sperm binding protein 1. | 0.650 |
IZUMO4 | KLK1E2 | ENSECAP00000055166 | ENSECAP00000009529 | IZUMO family member 4. | Kallikrein-1E2; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin; Belongs to the peptidase S1 family. Kallikrein subfamily. | 0.686 |
KLK1 | F7DW27_HORSE | ENSECAP00000018835 | ENSECAP00000012812 | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | Peptidase S1 domain-containing protein. | 0.900 |