Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
CXCL11C-X-C motif chemokine. (100 aa)    
Predicted Functional Partners:
CXCL10
C-X-C motif chemokine.
  
0.999
CXCR3
C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.
    
 0.993
CCL5
C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family.
   
 0.993
LOC100630489
C-X-C motif chemokine.
    
 0.987
CXCL12
C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family.
   
 0.981
PPBP
C-X-C motif chemokine.
   
 0.976
CXCL14
C-X-C motif chemokine ligand 14.
    
 
 0.976
CCL1
SCY domain-containing protein.
    
 0.969
LOC100063059
SCY domain-containing protein.
   
 0.966
CCL25
C-C motif chemokine ligand 25.
    
 0.966
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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