IL24 protein (Equus caballus) - STRING interaction network

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Score

IL24

Interleukin 24. (206 aa)

Predicted Functional Partners:

IL22RA1

0.985

NCK1

0.981

IL10

0.964

IL22

0.964

IL26

0.960

IL20RA

0.949

IL20

0.904

IL22RA2

0.903

IL19

0.899

IL10RB

0.853

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IL10	IL10RB	ENSECAP00000007097	ENSECAP00000005480	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 10 receptor subunit beta.	0.989
IL10	IL19	ENSECAP00000007097	ENSECAP00000035280	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 19.	0.926
IL10	IL20	ENSECAP00000007097	ENSECAP00000034814	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 20.	0.910
IL10	IL20RA	ENSECAP00000007097	ENSECAP00000005747	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 20 receptor subunit alpha.	0.926
IL10	IL22	ENSECAP00000007097	ENSECAP00000017097	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin-22-like protein.	0.989
IL10	IL22RA1	ENSECAP00000007097	ENSECAP00000013856	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 22 receptor subunit alpha 1.	0.896
IL10	IL22RA2	ENSECAP00000007097	ENSECAP00000006850	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 22 receptor subunit alpha 2.	0.901
IL10	IL24	ENSECAP00000007097	ENSECAP00000010073	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 24.	0.964
IL10	IL26	ENSECAP00000007097	ENSECAP00000037161	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 26.	0.946
IL10	NCK1	ENSECAP00000007097	ENSECAP00000047950	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 20 receptor subunit beta.	0.806
IL10RB	IL10	ENSECAP00000005480	ENSECAP00000007097	Interleukin 10 receptor subunit beta.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.989
IL10RB	IL19	ENSECAP00000005480	ENSECAP00000035280	Interleukin 10 receptor subunit beta.	Interleukin 19.	0.856
IL10RB	IL20	ENSECAP00000005480	ENSECAP00000034814	Interleukin 10 receptor subunit beta.	Interleukin 20.	0.904
IL10RB	IL20RA	ENSECAP00000005480	ENSECAP00000005747	Interleukin 10 receptor subunit beta.	Interleukin 20 receptor subunit alpha.	0.913
IL10RB	IL22	ENSECAP00000005480	ENSECAP00000017097	Interleukin 10 receptor subunit beta.	Interleukin-22-like protein.	0.987
IL10RB	IL22RA1	ENSECAP00000005480	ENSECAP00000013856	Interleukin 10 receptor subunit beta.	Interleukin 22 receptor subunit alpha 1.	0.976
IL10RB	IL22RA2	ENSECAP00000005480	ENSECAP00000006850	Interleukin 10 receptor subunit beta.	Interleukin 22 receptor subunit alpha 2.	0.910
IL10RB	IL24	ENSECAP00000005480	ENSECAP00000010073	Interleukin 10 receptor subunit beta.	Interleukin 24.	0.853
IL10RB	IL26	ENSECAP00000005480	ENSECAP00000037161	Interleukin 10 receptor subunit beta.	Interleukin 26.	0.959
IL10RB	NCK1	ENSECAP00000005480	ENSECAP00000047950	Interleukin 10 receptor subunit beta.	Interleukin 20 receptor subunit beta.	0.804