Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
CLCN1Chloride channel protein. (989 aa)    
Predicted Functional Partners:
MBNL1
Muscleblind like splicing regulator 1.
      
 0.878
CELF1
CUGBP Elav-like family member 1.
      
 0.853
SCN4A
Sodium channel protein type 4 subunit alpha; Pore-forming subunit of a voltage-gated sodium channel complex through which Na(+) ions pass in accordance with their electrochemical gradient. Alternates between resting, activated and inactivated states (By similarity). Required for normal muscle fiber excitability, normal muscle contraction and relaxation cycles, and constant muscle strength in the presence of fluctuating K(+) levels.
   
  
 0.827
MBNL3
Muscleblind like splicing regulator 3.
      
 0.812
MBNL2
Muscleblind like splicing regulator 2.
      
 0.810
DMPK
DM1 protein kinase.
   
 
 0.784
CRBN
Cereblon.
    
 
 0.765
ATP2A1
Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.
   
 
 0.728
INSR
Tyrosine-protein kinase receptor.
     
 0.717
BSND
Barttin CLCNK type accessory beta subunit.
   
 
 0.716
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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