STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PLEKHG6Pleckstrin homology and RhoGEF domain containing G6. (792 aa)    
Predicted Functional Partners:
TRNP1
TMF1 regulated nuclear protein 1.
      
 0.774
TNF
Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]
    
 0.725
RIPK1
Receptor interacting serine/threonine kinase 1.
   
 0.697
TRADD
TNFRSF1A associated via death domain.
    
 0.689
LTA
Tumor necrosis factor ligand 1E; Belongs to the tumor necrosis factor family.
    
 0.650
F7CNV6_HORSE
Uncharacterized protein.
    
 0.650
CYLD
CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family.
    
 0.640
TNFAIP3
TNF alpha induced protein 3.
    
 0.639
RBCK1
RANBP2-type and C3HC4-type zinc finger containing 1.
    
 0.626
F6THK5_HORSE
Uncharacterized protein.
   
 0.583
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.