STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TMEM97Transmembrane protein 97; Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins. (176 aa)    
Predicted Functional Partners:
ZDHHC19
Uncharacterized protein.
      
 0.852
PGRMC1
Progesterone receptor membrane component 1; Belongs to the cytochrome b5 family.
   
  
 0.733
SIGMAR1
Sigma non-opioid intracellular receptor 1.
   
  
 0.723
NPC1L1
NPC1 like intracellular cholesterol transporter 1.
      
 0.644
PHF6
PHD finger protein 6.
   
 
 0.632
SUPT3H
SPT3 homolog, SAGA and STAGA complex component.
      
 0.627
NPC1
NPC intracellular cholesterol transporter 1.
   
  
 0.618
YIF1A
Yip1 interacting factor homolog A, membrane trafficking protein.
   
  
 0.576
SREBF2
Sterol regulatory element binding transcription factor 2.
      
 0.543
LGALS4
Galectin.
    
 0.533
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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