Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PRF1Perforin 1. (555 aa)    
Predicted Functional Partners:
GNLY
Antimicrobial peptide NK-lysin; May be an effector molecule of cytotoxic activity. Has antimicrobial activity (By similarity).
   
 
 0.972
NKG7
Natural killer cell granule protein 7.
   
  
 0.965
KLRD1
C-type lectin domain-containing protein.
   
 0.932
CD8A
CD8a molecule.
   
  
 0.898
CTSW
Cathepsin W; Belongs to the peptidase C1 family.
   
 
 0.890
GZMA
Granzyme A; Belongs to the peptidase S1 family.
   
 0.880
FASLG
Tumor necrosis factor ligand 1A; Belongs to the tumor necrosis factor family.
   
 0.822
LOC102149514
Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.
   
 0.815
ENSECAP00000044250
Peptidase S1 domain-containing protein.
   
 0.815
IFNG
Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.
   
  
 0.768
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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