STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PRF1Perforin 1. (555 aa)    
Predicted Functional Partners:
GNLY
Antimicrobial peptide NK-lysin; May be an effector molecule of cytotoxic activity. Has antimicrobial activity (By similarity).
   
  
 0.846
NKG7
Natural killer cell granule protein 7.
   
  
 0.817
CD8A
CD8a molecule.
   
  
 0.789
FASLG
Tumor necrosis factor ligand 1A; Belongs to the tumor necrosis factor family.
   
 0.789
GZMA
Granzyme A; Belongs to the peptidase S1 family.
   
 0.776
KLRD1
C-type lectin domain-containing protein.
   
 0.727
ENSECAP00000044250
Peptidase S1 domain-containing protein.
   
 0.716
C1QC
Complement C1q C chain.
   
 0.672
LOC100055651
Peptidase S1 domain-containing protein.
   
 0.626
LOC100049805
Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.
   
 0.625
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.