F6SJC9_HORSE protein (Equus caballus) - STRING interaction network

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F6SJC9_HORSE

Ig-like domain-containing protein. (324 aa)

Predicted Functional Partners:

TFRC

0.966

TFR2

0.941

HJV

0.861

EPO

0.739

RPA2

0.666

B2M

0.666

RGMA

0.622

HAMP

0.522

SLC11A2

0.477

TMPRSS6

0.473

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B2M	F6SJC9_HORSE	ENSECAP00000048553	ENSECAP00000010282	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Ig-like domain-containing protein.	0.666
B2M	TFR2	ENSECAP00000048553	ENSECAP00000022296	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Transferrin receptor 2.	0.416
B2M	TFRC	ENSECAP00000048553	ENSECAP00000021947	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Transferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity).	0.763
EPO	F6SJC9_HORSE	ENSECAP00000037030	ENSECAP00000010282	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Ig-like domain-containing protein.	0.739
EPO	HAMP	ENSECAP00000037030	ENSECAP00000026484	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Hepcidin antimicrobial peptide.	0.622
EPO	HJV	ENSECAP00000037030	ENSECAP00000031541	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Hemojuvelin BMP co-receptor.	0.639
EPO	RGMA	ENSECAP00000037030	ENSECAP00000041857	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Repulsive guidance molecule BMP co-receptor a.	0.516
EPO	TFR2	ENSECAP00000037030	ENSECAP00000022296	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Transferrin receptor 2.	0.454
EPO	TFRC	ENSECAP00000037030	ENSECAP00000021947	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Transferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity).	0.643
EPO	TMPRSS6	ENSECAP00000037030	ENSECAP00000026192	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Transmembrane serine protease 6; Belongs to the peptidase S1 family.	0.404
F6SJC9_HORSE	B2M	ENSECAP00000010282	ENSECAP00000048553	Ig-like domain-containing protein.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	0.666
F6SJC9_HORSE	EPO	ENSECAP00000010282	ENSECAP00000037030	Ig-like domain-containing protein.	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	0.739
F6SJC9_HORSE	HAMP	ENSECAP00000010282	ENSECAP00000026484	Ig-like domain-containing protein.	Hepcidin antimicrobial peptide.	0.522
F6SJC9_HORSE	HJV	ENSECAP00000010282	ENSECAP00000031541	Ig-like domain-containing protein.	Hemojuvelin BMP co-receptor.	0.861
F6SJC9_HORSE	RGMA	ENSECAP00000010282	ENSECAP00000041857	Ig-like domain-containing protein.	Repulsive guidance molecule BMP co-receptor a.	0.622
F6SJC9_HORSE	RPA2	ENSECAP00000010282	ENSECAP00000004230	Ig-like domain-containing protein.	Replication protein A2.	0.666
F6SJC9_HORSE	SLC11A2	ENSECAP00000010282	ENSECAP00000033731	Ig-like domain-containing protein.	Solute carrier family 11 member 2.	0.477
F6SJC9_HORSE	TFR2	ENSECAP00000010282	ENSECAP00000022296	Ig-like domain-containing protein.	Transferrin receptor 2.	0.941
F6SJC9_HORSE	TFRC	ENSECAP00000010282	ENSECAP00000021947	Ig-like domain-containing protein.	Transferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity).	0.966
F6SJC9_HORSE	TMPRSS6	ENSECAP00000010282	ENSECAP00000026192	Ig-like domain-containing protein.	Transmembrane serine protease 6; Belongs to the peptidase S1 family.	0.473