Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
COMTD1Catechol-O-methyltransferase domain containing 1. (262 aa)    
Predicted Functional Partners:
NAXE
NAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
  
  
 0.860
PRSS35
Serine protease 35.
      
 0.802
SLC25A16
Solute carrier family 25 member 16; Belongs to the mitochondrial carrier (TC 2.A.29) family.
      
 0.801
COX11
Cytochrome c oxidase copper chaperone COX11.
   
  
 0.796
DUS2
Dihydrouridine synthase 2.
  
  
 0.716
COPRS
Coordinator of PRMT5 and differentiation stimulator.
      
 0.668
PAXBP1
PAX3 and PAX7 binding protein 1.
      
 0.666
FDPS
Uncharacterized protein; Belongs to the FPP/GGPP synthase family.
  
  
 0.648
MAP6D1
MAP6 domain containing 1.
    
 
 0.630
TK1
Thymidine kinase.
  
 
  0.627
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.