STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
WDR44WD repeat domain 44. (914 aa)    
Predicted Functional Partners:
RABGEF1
RAB guanine nucleotide exchange factor 1.
   
  
 0.860
PTPRM
Protein tyrosine phosphatase receptor type M.
      
 0.798
MAL2
Mal, T cell differentiation protein 2 (gene/pseudogene).
      
 0.766
AQR
RNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing.
      
 0.728
RAB3GAP2
Uncharacterized protein.
      
 0.699
RAB3GAP1
RAB3 GTPase activating protein catalytic subunit 1.
   
  
 0.679
GNA11
G protein subunit alpha 11.
      
 0.676
EFEMP1
EGF containing fibulin extracellular matrix protein 1.
      
 0.649
VAPB
VAMP associated protein B and C.
   
 
 0.609
VAPA
VAMP associated protein A.
   
 
 0.602
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.