| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGO1 | AGO2 | ENSECAP00000022121 | ENSECAP00000005648 | Argonaute RISC component 1; Belongs to the argonaute family. | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | 0.944 |
| AGO1 | CNOT1 | ENSECAP00000022121 | ENSECAP00000008876 | Argonaute RISC component 1; Belongs to the argonaute family. | CCR4-NOT transcription complex subunit 1. | 0.693 |
| AGO1 | TNRC6C | ENSECAP00000022121 | ENSECAP00000010397 | Argonaute RISC component 1; Belongs to the argonaute family. | Trinucleotide repeat containing adaptor 6C. | 0.856 |
| AGO2 | AGO1 | ENSECAP00000005648 | ENSECAP00000022121 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | Argonaute RISC component 1; Belongs to the argonaute family. | 0.944 |
| AGO2 | AGO4 | ENSECAP00000005648 | ENSECAP00000022346 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. | 0.942 |
| AGO2 | CNOT1 | ENSECAP00000005648 | ENSECAP00000008876 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | CCR4-NOT transcription complex subunit 1. | 0.882 |
| AGO2 | CNOT2 | ENSECAP00000005648 | ENSECAP00000024397 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | CCR4-NOT transcription complex subunit 2. | 0.429 |
| AGO2 | CNOT8 | ENSECAP00000005648 | ENSECAP00000011166 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | CCR4-NOT transcription complex subunit 8. | 0.401 |
| AGO2 | TNRC6C | ENSECAP00000005648 | ENSECAP00000010397 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | Trinucleotide repeat containing adaptor 6C. | 0.988 |
| AGO4 | AGO2 | ENSECAP00000022346 | ENSECAP00000005648 | Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | 0.942 |
| AGO4 | CNOT1 | ENSECAP00000022346 | ENSECAP00000008876 | Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. | CCR4-NOT transcription complex subunit 1. | 0.494 |
| AGO4 | TNRC6C | ENSECAP00000022346 | ENSECAP00000010397 | Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. | Trinucleotide repeat containing adaptor 6C. | 0.894 |
| CNOT1 | AGO1 | ENSECAP00000008876 | ENSECAP00000022121 | CCR4-NOT transcription complex subunit 1. | Argonaute RISC component 1; Belongs to the argonaute family. | 0.693 |
| CNOT1 | AGO2 | ENSECAP00000008876 | ENSECAP00000005648 | CCR4-NOT transcription complex subunit 1. | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | 0.882 |
| CNOT1 | AGO4 | ENSECAP00000008876 | ENSECAP00000022346 | CCR4-NOT transcription complex subunit 1. | Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. | 0.494 |
| CNOT1 | CNOT2 | ENSECAP00000008876 | ENSECAP00000024397 | CCR4-NOT transcription complex subunit 1. | CCR4-NOT transcription complex subunit 2. | 0.999 |
| CNOT1 | CNOT3 | ENSECAP00000008876 | ENSECAP00000044850 | CCR4-NOT transcription complex subunit 1. | CCR4-NOT transcription complex subunit 3. | 0.997 |
| CNOT1 | CNOT8 | ENSECAP00000008876 | ENSECAP00000011166 | CCR4-NOT transcription complex subunit 1. | CCR4-NOT transcription complex subunit 8. | 0.999 |
| CNOT1 | GIGYF1 | ENSECAP00000008876 | ENSECAP00000015344 | CCR4-NOT transcription complex subunit 1. | GRB10 interacting GYF protein 1. | 0.563 |
| CNOT1 | PAN2 | ENSECAP00000008876 | ENSECAP00000017631 | CCR4-NOT transcription complex subunit 1. | PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] | 0.457 |
