Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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ARNTLAryl hydrocarbon receptor nuclear translocator-like protein 1; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressur [...] (626 aa)    
Predicted Functional Partners:
CRY2
Cryptochrome circadian regulator 2.
   
 0.999
CRY1
Cryptochrome circadian regulator 1.
   
 0.999
NR1D1
Nuclear receptor subfamily 1 group D member 1.
    
 0.995
DBP
D-box binding PAR bZIP transcription factor.
    
 0.987
NR1D2
Nuclear receptor subfamily 1 group D member 2.
    
 0.985
RORA
RAR related orphan receptor A.
   
 0.985
ARNTL2
Aryl hydrocarbon receptor nuclear translocator like 2.
  
0.983
BHLHE40
Basic helix-loop-helix family member e40.
    
 0.979
RORC
RAR related orphan receptor C.
    
 0.978
SIRT1
Sirtuin 1.
   
 0.974
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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