STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BACE1Beta-secretase 1; Belongs to the peptidase A1 family. (501 aa)    
Predicted Functional Partners:
RTN3
Reticulon.
   
 0.968
APP
Amyloid beta precursor protein.
    
 0.966
RTN4
Reticulon.
   
 0.962
IDE
Insulin degrading enzyme.
     
 0.941
PSEN1
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
   
 
 0.928
MMEL1
Membrane metalloendopeptidase like 1.
      
 0.920
BACE2
Beta-secretase 2; Belongs to the peptidase A1 family.
  
  
0.908
NCSTN
Nicastrin.
    
 
 0.901
GGA1
Golgi associated, gamma adaptin ear containing, ARF binding protein 1.
    
 0.882
ADAM10
ADAM metallopeptidase domain 10.
    
 
 0.849
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.