STOM protein (Equus caballus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

STOM

Stomatin. (284 aa)

Predicted Functional Partners:

ENSECAP00000039988

0.886

PHB2

0.885

PHB

0.838

ASIC3

0.811

RHAG

0.798

FLOT1

0.795

FLOT2

0.779

SRI

0.716

PIEZO1

0.653

ASIC4

0.651

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASIC3	ASIC4	ENSECAP00000051347	ENSECAP00000017056	Acid sensing ion channel subunit 3; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.	Acid sensing ion channel subunit family member 4; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.	0.936
ASIC3	PIEZO1	ENSECAP00000051347	ENSECAP00000026684	Acid sensing ion channel subunit 3; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.	Piezo-type mechanosensitive ion channel component.	0.512
ASIC3	STOM	ENSECAP00000051347	ENSECAP00000010841	Acid sensing ion channel subunit 3; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.	Stomatin.	0.811
ASIC4	ASIC3	ENSECAP00000017056	ENSECAP00000051347	Acid sensing ion channel subunit family member 4; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.	Acid sensing ion channel subunit 3; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.	0.936
ASIC4	STOM	ENSECAP00000017056	ENSECAP00000010841	Acid sensing ion channel subunit family member 4; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.	Stomatin.	0.651
ENSECAP00000039988	FLOT1	ENSECAP00000039988	ENSECAP00000019710	Prohibitin.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.615
ENSECAP00000039988	FLOT2	ENSECAP00000039988	ENSECAP00000010141	Prohibitin.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.554
ENSECAP00000039988	PHB	ENSECAP00000039988	ENSECAP00000028950	Prohibitin.	Prohibitin.	0.996
ENSECAP00000039988	STOM	ENSECAP00000039988	ENSECAP00000010841	Prohibitin.	Stomatin.	0.886
FLOT1	ENSECAP00000039988	ENSECAP00000019710	ENSECAP00000039988	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	Prohibitin.	0.615
FLOT1	FLOT2	ENSECAP00000019710	ENSECAP00000010141	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.996
FLOT1	PHB	ENSECAP00000019710	ENSECAP00000028950	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	Prohibitin.	0.598
FLOT1	PHB2	ENSECAP00000019710	ENSECAP00000014670	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	Prohibitin.	0.603
FLOT1	STOM	ENSECAP00000019710	ENSECAP00000010841	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	Stomatin.	0.795
FLOT2	ENSECAP00000039988	ENSECAP00000010141	ENSECAP00000039988	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	Prohibitin.	0.554
FLOT2	FLOT1	ENSECAP00000010141	ENSECAP00000019710	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.996
FLOT2	PHB	ENSECAP00000010141	ENSECAP00000028950	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	Prohibitin.	0.544
FLOT2	PHB2	ENSECAP00000010141	ENSECAP00000014670	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	Prohibitin.	0.533
FLOT2	STOM	ENSECAP00000010141	ENSECAP00000010841	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	Stomatin.	0.779
PHB	ENSECAP00000039988	ENSECAP00000028950	ENSECAP00000039988	Prohibitin.	Prohibitin.	0.996

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Network Stats

Network Stats analysis is still ongoing, please wait ...

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006796

Phosphate-containing compound metabolic process

9 of 236

1.01

1.17

2.57e-07

GO:0044271

Cellular nitrogen compound biosynthetic process

9 of 327

0.86

0.88

3.63e-06

GO:1901566

Organonitrogen compound biosynthetic process

9 of 407

0.77

0.72

2.10e-05

GO:0006139

Nucleobase-containing compound metabolic process

9 of 537

0.65

0.55

0.00022

GO:0034641

Cellular nitrogen compound metabolic process

10 of 707

0.57

0.49

0.00014

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046933

Proton-transporting ATP synthase activity, rotational mechanism

8 of 9

2.37

6.45

1.76e-14

GO:0046961

Proton-transporting ATPase activity, rotational mechanism

2 of 3

2.25

1.23

0.0050

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045259

Proton-transporting ATP synthase complex

8 of 9

2.37

6.71

3.72e-15

GO:0045261

Proton-transporting ATP synthase complex, catalytic core F(1)

5 of 6

2.34

4.18

3.68e-09

GO:0045263

Proton-transporting ATP synthase complex, coupling factor F(o)

3 of 3

2.42

2.56

1.40e-05

GO:0005886

Plasma membrane

8 of 491

0.64

0.51

0.00095

GO:0005622

Intracellular anatomical structure

10 of 1040

0.41

0.33

0.0029

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:22479625

(2012) Comparative analysis of gene content evolution in phytoplasmas and mycoplasmas.

4 of 102

1.02

0.56

0.0355

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:249

ATP synthesis

8 of 8

2.42

6.65

1.05e-14

CL:84

Ribosome, and Ribonucleoside triphosphate biosynthetic process

10 of 91

1.46

2.77

5.39e-12

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pth00190

Oxidative phosphorylation

9 of 19

2.1

6.04

8.55e-16

pth01100

Metabolic pathways

8 of 503

0.63

0.47

0.0041

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0045259

Proton-transporting ATP synthase complex

8 of 10

2.33

6.39

1.27e-14

GOCC:0045261

Proton-transporting ATP synthase complex, catalytic core F(1)

5 of 5

2.42

4.26

3.81e-09

GOCC:0045263

Proton-transporting ATP synthase complex, coupling factor F(o)

3 of 5

2.2

2.13

7.39e-05

GOCC:0032991

Protein-containing complex

9 of 435

0.74

0.67

6.39e-05

GOCC:0005622

Intracellular

10 of 995

0.43

0.34

0.0039

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0375

Hydrogen ion transport

8 of 8

2.42

6.87

3.09e-15

KW-0066

ATP synthesis

8 of 8

2.42

6.87

3.09e-15

KW-0139

CF(1)

5 of 5

2.42

4.29

3.15e-09

KW-0138

CF(0)

3 of 3

2.42

2.46

2.19e-05

KW-1003

Cell membrane

8 of 110

1.29

1.85

2.66e-08

(more ...)

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