STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CORO6Coronin; Belongs to the WD repeat coronin family. (472 aa)    
Predicted Functional Partners:
ARHGEF5
Rho guanine nucleotide exchange factor 5.
      
 0.880
RAPGEF1
Rap guanine nucleotide exchange factor 1.
   
 
 0.754
ELMO2
Engulfment and cell motility 2.
   
  
 0.743
COPZ2
Coatomer subunit zeta; The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.
   
  
 0.658
SORBS1
Sorbin and SH3 domain containing 1.
   
 
 0.633
DOCK1
Dedicator of cytokinesis 1; Belongs to the DOCK family.
   
  
 0.631
IRGQ
Immunity related GTPase Q.
   
 
 0.615
DHFR
DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.
    
 0.554
ACTR2
Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.
   
 
 0.529
DUT
Deoxyuridine triphosphatase.
      0.527
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.