node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCL5 | CD3D | ENSECAP00000022430 | ENSECAP00000015856 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | CD3d molecule. | 0.651 |
CCL5 | CD8A | ENSECAP00000022430 | ENSECAP00000011123 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | CD8a molecule. | 0.752 |
CCL5 | ENSECAP00000044250 | ENSECAP00000022430 | ENSECAP00000044250 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | Peptidase S1 domain-containing protein. | 0.680 |
CCL5 | GNLY | ENSECAP00000022430 | ENSECAP00000031488 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | Antimicrobial peptide NK-lysin; May be an effector molecule of cytotoxic activity. Has antimicrobial activity (By similarity). | 0.517 |
CCL5 | GZMA | ENSECAP00000022430 | ENSECAP00000020798 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | Granzyme A; Belongs to the peptidase S1 family. | 0.711 |
CCL5 | KLRD1 | ENSECAP00000022430 | ENSECAP00000036098 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | C-type lectin domain-containing protein. | 0.480 |
CCL5 | NKG7 | ENSECAP00000022430 | ENSECAP00000011861 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | Natural killer cell granule protein 7. | 0.785 |
CCL5 | PRF1 | ENSECAP00000022430 | ENSECAP00000010232 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | Perforin 1. | 0.550 |
CD3D | CCL5 | ENSECAP00000015856 | ENSECAP00000022430 | CD3d molecule. | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | 0.651 |
CD3D | CD8A | ENSECAP00000015856 | ENSECAP00000011123 | CD3d molecule. | CD8a molecule. | 0.899 |
CD3D | CTSW | ENSECAP00000015856 | ENSECAP00000019268 | CD3d molecule. | Cathepsin W; Belongs to the peptidase C1 family. | 0.411 |
CD3D | ENSECAP00000044250 | ENSECAP00000015856 | ENSECAP00000044250 | CD3d molecule. | Peptidase S1 domain-containing protein. | 0.450 |
CD3D | GNLY | ENSECAP00000015856 | ENSECAP00000031488 | CD3d molecule. | Antimicrobial peptide NK-lysin; May be an effector molecule of cytotoxic activity. Has antimicrobial activity (By similarity). | 0.608 |
CD3D | GZMA | ENSECAP00000015856 | ENSECAP00000020798 | CD3d molecule. | Granzyme A; Belongs to the peptidase S1 family. | 0.725 |
CD3D | KLRD1 | ENSECAP00000015856 | ENSECAP00000036098 | CD3d molecule. | C-type lectin domain-containing protein. | 0.500 |
CD3D | NKG7 | ENSECAP00000015856 | ENSECAP00000011861 | CD3d molecule. | Natural killer cell granule protein 7. | 0.796 |
CD8A | CCL5 | ENSECAP00000011123 | ENSECAP00000022430 | CD8a molecule. | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | 0.752 |
CD8A | CD3D | ENSECAP00000011123 | ENSECAP00000015856 | CD8a molecule. | CD3d molecule. | 0.899 |
CD8A | CTSW | ENSECAP00000011123 | ENSECAP00000019268 | CD8a molecule. | Cathepsin W; Belongs to the peptidase C1 family. | 0.415 |
CD8A | ENSECAP00000044250 | ENSECAP00000011123 | ENSECAP00000044250 | CD8a molecule. | Peptidase S1 domain-containing protein. | 0.531 |