INSRR protein (Equus caballus) - STRING interaction network

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Score

INSRR

Tyrosine-protein kinase receptor. (1334 aa)

Predicted Functional Partners:

INS

0.985

SOS1

0.938

SOS2

0.931

IGF1

0.911

INSR

0.874

PTPN1

0.870

PIK3R1

0.845

SH2D2A

0.815

PIK3R2

0.812

LOC100052122

0.812

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IGF1	INS	ENSECAP00000033255	ENSECAP00000022114	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.995
IGF1	INSR	ENSECAP00000033255	ENSECAP00000008032	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	Tyrosine-protein kinase receptor.	0.996
IGF1	INSRR	ENSECAP00000033255	ENSECAP00000012547	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	Tyrosine-protein kinase receptor.	0.911
IGF1	SOS1	ENSECAP00000033255	ENSECAP00000053950	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.476
IGF1	SOS2	ENSECAP00000033255	ENSECAP00000045981	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	SOS Ras/Rho guanine nucleotide exchange factor 2.	0.410
INS	IGF1	ENSECAP00000022114	ENSECAP00000033255	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	0.995
INS	INSR	ENSECAP00000022114	ENSECAP00000008032	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Tyrosine-protein kinase receptor.	0.999
INS	INSRR	ENSECAP00000022114	ENSECAP00000012547	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Tyrosine-protein kinase receptor.	0.985
INS	PIK3R1	ENSECAP00000022114	ENSECAP00000017836	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Phosphoinositide-3-kinase regulatory subunit 1.	0.421
INS	PTPN1	ENSECAP00000022114	ENSECAP00000023440	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Protein tyrosine phosphatase non-receptor type 1.	0.436
INS	SOS1	ENSECAP00000022114	ENSECAP00000053950	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.519
INS	SOS2	ENSECAP00000022114	ENSECAP00000045981	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	SOS Ras/Rho guanine nucleotide exchange factor 2.	0.423
INSR	IGF1	ENSECAP00000008032	ENSECAP00000033255	Tyrosine-protein kinase receptor.	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	0.996
INSR	INS	ENSECAP00000008032	ENSECAP00000022114	Tyrosine-protein kinase receptor.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.999
INSR	INSRR	ENSECAP00000008032	ENSECAP00000012547	Tyrosine-protein kinase receptor.	Tyrosine-protein kinase receptor.	0.874
INSR	LOC100052122	ENSECAP00000008032	ENSECAP00000031451	Tyrosine-protein kinase receptor.	Uncharacterized protein.	0.812
INSR	PIK3R1	ENSECAP00000008032	ENSECAP00000017836	Tyrosine-protein kinase receptor.	Phosphoinositide-3-kinase regulatory subunit 1.	0.954
INSR	PIK3R2	ENSECAP00000008032	ENSECAP00000023307	Tyrosine-protein kinase receptor.	Uncharacterized protein.	0.812
INSR	PTPN1	ENSECAP00000008032	ENSECAP00000023440	Tyrosine-protein kinase receptor.	Protein tyrosine phosphatase non-receptor type 1.	0.999
INSR	SH2D2A	ENSECAP00000008032	ENSECAP00000044244	Tyrosine-protein kinase receptor.	SH2 domain containing 2A.	0.420