node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACR | F7DW27_HORSE | ENSECAP00000011677 | ENSECAP00000012812 | Acrosin; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome. | Peptidase S1 domain-containing protein. | 0.531 |
ACR | MET | ENSECAP00000011677 | ENSECAP00000008993 | Acrosin; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome. | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | 0.496 |
AR | F7DW27_HORSE | ENSECAP00000008070 | ENSECAP00000012812 | Androgen receptor. | Peptidase S1 domain-containing protein. | 0.467 |
AR | KLK1 | ENSECAP00000008070 | ENSECAP00000018835 | Androgen receptor. | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | 0.467 |
F2 | F7DW27_HORSE | ENSECAP00000009701 | ENSECAP00000012812 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Peptidase S1 domain-containing protein. | 0.440 |
F2 | KNG1 | ENSECAP00000009701 | ENSECAP00000051902 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Kininogen 1. | 0.728 |
F2 | MET | ENSECAP00000009701 | ENSECAP00000008993 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | 0.523 |
F2 | SERPING1 | ENSECAP00000009701 | ENSECAP00000008891 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Serpin family G member 1; Belongs to the serpin family. | 0.478 |
F7DW27_HORSE | ACR | ENSECAP00000012812 | ENSECAP00000011677 | Peptidase S1 domain-containing protein. | Acrosin; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome. | 0.531 |
F7DW27_HORSE | AR | ENSECAP00000012812 | ENSECAP00000008070 | Peptidase S1 domain-containing protein. | Androgen receptor. | 0.467 |
F7DW27_HORSE | F2 | ENSECAP00000012812 | ENSECAP00000009701 | Peptidase S1 domain-containing protein. | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | 0.440 |
F7DW27_HORSE | KLK1 | ENSECAP00000012812 | ENSECAP00000018835 | Peptidase S1 domain-containing protein. | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | 0.900 |
F7DW27_HORSE | KLK1E2 | ENSECAP00000012812 | ENSECAP00000009529 | Peptidase S1 domain-containing protein. | Kallikrein-1E2; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin; Belongs to the peptidase S1 family. Kallikrein subfamily. | 0.901 |
F7DW27_HORSE | KNG1 | ENSECAP00000012812 | ENSECAP00000051902 | Peptidase S1 domain-containing protein. | Kininogen 1. | 0.784 |
F7DW27_HORSE | MET | ENSECAP00000012812 | ENSECAP00000008993 | Peptidase S1 domain-containing protein. | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | 0.501 |
F7DW27_HORSE | MRE11 | ENSECAP00000012812 | ENSECAP00000000475 | Peptidase S1 domain-containing protein. | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | 0.494 |
F7DW27_HORSE | SERPING1 | ENSECAP00000012812 | ENSECAP00000008891 | Peptidase S1 domain-containing protein. | Serpin family G member 1; Belongs to the serpin family. | 0.500 |
F7DW27_HORSE | TMC4 | ENSECAP00000012812 | ENSECAP00000010666 | Peptidase S1 domain-containing protein. | Transmembrane channel-like protein. | 0.657 |
KLK1 | AR | ENSECAP00000018835 | ENSECAP00000008070 | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | Androgen receptor. | 0.467 |
KLK1 | F7DW27_HORSE | ENSECAP00000018835 | ENSECAP00000012812 | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | Peptidase S1 domain-containing protein. | 0.900 |