PROC protein (Equus caballus) - STRING interaction network

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PROC

Vitamin K-dependent protein C; Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function. Belongs to the peptidase S1 family. (640 aa)

Predicted Functional Partners:

SERPINF2

0.972

F8

0.971

F5

0.968

THBD

0.965

F2R

0.951

F2

0.950

SERPINA5

0.944

PROCR

0.943

SERPINE1

0.932

SERPINB2

0.928

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F2	F2R	ENSECAP00000009701	ENSECAP00000002827	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family.	0.997
F2	F5	ENSECAP00000009701	ENSECAP00000005079	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Coagulation factor V; Belongs to the multicopper oxidase family.	0.998
F2	F8	ENSECAP00000009701	ENSECAP00000029284	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Coagulation factor VIII; Belongs to the multicopper oxidase family.	0.902
F2	PROC	ENSECAP00000009701	ENSECAP00000026753	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Vitamin K-dependent protein C; Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function. Belongs to the peptidase S1 family.	0.950
F2	PROCR	ENSECAP00000009701	ENSECAP00000021910	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Protein C receptor.	0.721
F2	SERPINA5	ENSECAP00000009701	ENSECAP00000036665	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Serpin family A member 5; Belongs to the serpin family.	0.968
F2	SERPINB2	ENSECAP00000009701	ENSECAP00000002468	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Serpin family B member 10; Belongs to the serpin family.	0.628
F2	SERPINE1	ENSECAP00000009701	ENSECAP00000017450	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Serpin family E member 1; Belongs to the serpin family.	0.551
F2	SERPINF2	ENSECAP00000009701	ENSECAP00000052579	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Serpin family F member 2; Belongs to the serpin family.	0.884
F2	THBD	ENSECAP00000009701	ENSECAP00000003584	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Thrombomodulin.	0.998
F2R	F2	ENSECAP00000002827	ENSECAP00000009701	Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.997
F2R	PROC	ENSECAP00000002827	ENSECAP00000026753	Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family.	Vitamin K-dependent protein C; Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function. Belongs to the peptidase S1 family.	0.951
F2R	PROCR	ENSECAP00000002827	ENSECAP00000021910	Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family.	Protein C receptor.	0.738
F2R	THBD	ENSECAP00000002827	ENSECAP00000003584	Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family.	Thrombomodulin.	0.545
F5	F2	ENSECAP00000005079	ENSECAP00000009701	Coagulation factor V; Belongs to the multicopper oxidase family.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.998
F5	F8	ENSECAP00000005079	ENSECAP00000029284	Coagulation factor V; Belongs to the multicopper oxidase family.	Coagulation factor VIII; Belongs to the multicopper oxidase family.	0.712
F5	PROC	ENSECAP00000005079	ENSECAP00000026753	Coagulation factor V; Belongs to the multicopper oxidase family.	Vitamin K-dependent protein C; Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function. Belongs to the peptidase S1 family.	0.968
F5	SERPINA5	ENSECAP00000005079	ENSECAP00000036665	Coagulation factor V; Belongs to the multicopper oxidase family.	Serpin family A member 5; Belongs to the serpin family.	0.524
F5	THBD	ENSECAP00000005079	ENSECAP00000003584	Coagulation factor V; Belongs to the multicopper oxidase family.	Thrombomodulin.	0.558
F8	F2	ENSECAP00000029284	ENSECAP00000009701	Coagulation factor VIII; Belongs to the multicopper oxidase family.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.902

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