THAP9 protein (Equus caballus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

THAP9

THAP domain containing 9. (902 aa)

Predicted Functional Partners:

PGBD5

0.959

MPHOSPH6

0.954

JRKL

0.700

TIGD7

0.694

POGK

0.692

TIGD3

0.692

TIGD2

0.692

CENPBD1

0.692

TIGD5

0.692

TIGD6

0.651

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CENPBD1	PGBD5	ENSECAP00000034371	ENSECAP00000035702	Uncharacterized protein.	PiggyBac transposable element derived 5.	0.639
CENPBD1	POGK	ENSECAP00000034371	ENSECAP00000002275	Uncharacterized protein.	Pogo transposable element derived with KRAB domain.	0.908
CENPBD1	THAP9	ENSECAP00000034371	ENSECAP00000014250	Uncharacterized protein.	THAP domain containing 9.	0.692
CENPBD1	TIGD3	ENSECAP00000034371	ENSECAP00000004936	Uncharacterized protein.	Tigger transposable element derived 3.	0.425
CENPBD1	TIGD6	ENSECAP00000034371	ENSECAP00000003164	Uncharacterized protein.	Tigger transposable element derived 14.	0.424
JRKL	PGBD5	ENSECAP00000001253	ENSECAP00000035702	JRK like.	PiggyBac transposable element derived 5.	0.639
JRKL	POGK	ENSECAP00000001253	ENSECAP00000002275	JRK like.	Pogo transposable element derived with KRAB domain.	0.910
JRKL	THAP9	ENSECAP00000001253	ENSECAP00000014250	JRK like.	THAP domain containing 9.	0.700
JRKL	TIGD3	ENSECAP00000001253	ENSECAP00000004936	JRK like.	Tigger transposable element derived 3.	0.432
JRKL	TIGD5	ENSECAP00000001253	ENSECAP00000046172	JRK like.	Tigger transposable element derived 5.	0.566
MPHOSPH6	THAP9	ENSECAP00000028908	ENSECAP00000014250	M-phase phosphoprotein 6.	THAP domain containing 9.	0.954
PGBD5	CENPBD1	ENSECAP00000035702	ENSECAP00000034371	PiggyBac transposable element derived 5.	Uncharacterized protein.	0.639
PGBD5	JRKL	ENSECAP00000035702	ENSECAP00000001253	PiggyBac transposable element derived 5.	JRK like.	0.639
PGBD5	POGK	ENSECAP00000035702	ENSECAP00000002275	PiggyBac transposable element derived 5.	Pogo transposable element derived with KRAB domain.	0.730
PGBD5	THAP9	ENSECAP00000035702	ENSECAP00000014250	PiggyBac transposable element derived 5.	THAP domain containing 9.	0.959
PGBD5	TIGD2	ENSECAP00000035702	ENSECAP00000024264	PiggyBac transposable element derived 5.	Tigger transposable element derived 2.	0.639
PGBD5	TIGD3	ENSECAP00000035702	ENSECAP00000004936	PiggyBac transposable element derived 5.	Tigger transposable element derived 3.	0.639
PGBD5	TIGD5	ENSECAP00000035702	ENSECAP00000046172	PiggyBac transposable element derived 5.	Tigger transposable element derived 5.	0.639
PGBD5	TIGD6	ENSECAP00000035702	ENSECAP00000003164	PiggyBac transposable element derived 5.	Tigger transposable element derived 14.	0.537
PGBD5	TIGD7	ENSECAP00000035702	ENSECAP00000002976	PiggyBac transposable element derived 5.	Tigger transposable element derived 7.	0.669

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

38

average node degree:

6.91

avg. local clustering coefficient:

0.966

expected number of edges:

10

PPI enrichment p-value:

2.65e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0017185

Peptidyl-lysine hydroxylation

3 of 10

2.76

1.9

0.00034

GO:0030198

Extracellular matrix organization

5 of 235

1.61

1.47

0.00046

GO:0071230

Cellular response to amino acid stimulus

3 of 48

2.07

1.25

0.0041

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008475

Procollagen-lysine 5-dioxygenase activity

3 of 3

3.28

2.87

6.49e-06

GO:0005201

Extracellular matrix structural constituent

4 of 81

1.97

2.0

8.20e-05

GO:0031418

L-ascorbic acid binding

3 of 24

2.38

1.92

0.00024

GO:0050211

Procollagen galactosyltransferase activity

2 of 4

2.98

1.49

0.0020

GO:0005506

Iron ion binding

3 of 190

1.48

0.75

0.0259

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005581

Collagen trimer

5 of 50

2.28

3.55

7.33e-08

GO:0062023

Collagen-containing extracellular matrix

6 of 214

1.73

2.55

4.30e-07

GO:0098644

Complex of collagen trimers

3 of 13

2.64

2.55

1.86e-05

GO:0005583

Fibrillar collagen trimer

2 of 9

2.63

1.35

0.0035

GO:0005615

Extracellular space

6 of 1470

0.89

0.62

0.0080

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:33543004

(2019) Quantitative proteomic profiling of extracellular matrix and site-specific collagen post-translational modifications in an in vitro model of lung fibrosis.

6 of 52

2.34

3.98

1.06e-08

PMID:32384775

(2020) Genomic Identification, Evolution, and Expression Analysis of Collagen Genes Family in Water Buffalo during Lactation.

4 of 23

2.52

2.46

2.41e-05

PMID:33224464

(2020) Comprehensive proteomic atlas of skin biomatrix scaffolds reveals a supportive microenvironment for epidermal development.

4 of 55

2.14

1.75

0.00041

PMID:34901026

(2021) Time-Resolved Extracellular Matrix Atlas of the Developing Human Skin Dermis.

4 of 90

1.93

1.35

0.0021

PMID:25514169

(2014) RNA-seq analysis of equine conceptus transcripts during embryo fixation and capsule disappearance.

3 of 22

2.41

1.34

0.0033

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:13687

Banded collagen fibril, and Collagen biosynthesis and modifying enzymes

6 of 28

2.61

5.46

2.45e-11

CL:13729

Procollagen-lysine 5-dioxygenase activity, and Glycosyl transferase family 2

3 of 5

3.06

3.03

3.11e-06

CL:13688

Banded collagen fibril, and Collagen chain trimerization

3 of 20

2.46

2.16

8.80e-05

CL:13690

Mixed, incl. Banded collagen fibril, and TGF beta-induced protein/periostin

2 of 12

2.5

1.1

0.0096

CL:13938

Laminin interactions, and Collagen IV, non-collagenous

2 of 28

2.13

0.74

0.0418

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ecb04974

Protein digestion and absorption

5 of 92

2.01

3.02

2.90e-07

ecb00310

Lysine degradation

3 of 58

1.99

1.61

0.00064

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1650814

Collagen biosynthesis and modifying enzymes

9 of 99

2.24

6.77

1.71e-16

MAP-1474290

Collagen formation

9 of 111

2.19

6.55

2.28e-16

MAP-1474244

Extracellular matrix organization

9 of 350

1.69

3.62

3.52e-12

MAP-8948216

Collagen chain trimerization

3 of 44

2.11

1.62

0.00073

MAP-216083

Integrin cell surface interactions

3 of 69

1.92

1.35

0.0021

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0098644

Complex of collagen trimers

3 of 19

2.48

1.89

0.00030

GOCC:0005581

Collagen trimer

3 of 29

2.29

1.76

0.00048

GOCC:0005588

Collagen type V trimer

2 of 2

3.28

1.69

0.00091

GOCC:0030079

Light-harvesting complex, peripheral complex

2 of 4

2.98

1.58

0.0014

GOCC:0031012

Extracellular matrix

4 of 191

1.6

1.34

0.0010

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01391

Collagen triple helix repeat (20 copies)

5 of 72

2.12

3.0

6.10e-07

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR044861

Isopenicillin N synthase-like, Fe(2+) 2OG dioxygenase domain

3 of 3

3.28

2.83

7.60e-06

IPR001006

Procollagen-lysine 5-dioxygenase, conserved site

3 of 3

3.28

2.83

7.60e-06

IPR008160

Collagen triple helix repeat

5 of 74

2.11

2.76

2.16e-06

IPR006620

Prolyl 4-hydroxylase, alpha subunit

3 of 16

2.55

2.02

0.00018

IPR005123

Oxoglutarate/iron-dependent dioxygenase

3 of 20

2.46

1.91

0.00027

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00702

Prolyl 4-hydroxylase alpha subunit homologues.

3 of 16

2.55

2.19

8.47e-05

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