STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPP1Secreted phosphoprotein 1. (313 aa)    
Predicted Functional Partners:
CD44
CD44 antigen.
   
 0.999
ITGB1
Integrin beta; Belongs to the integrin beta chain family.
   
 0.987
ITGAV
Family with sequence similarity 171 member B; Belongs to the integrin alpha chain family.
   
 0.983
ITGB3
Integrin beta; Belongs to the integrin beta chain family.
    
 0.974
ITGA9
Integrin subunit alpha 9; Belongs to the integrin alpha chain family.
   
 0.968
ITGA4
Integrin subunit alpha 4; Belongs to the integrin alpha chain family.
   
 0.962
BGLAP
Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.
      
 0.961
ITGB5
Integrin beta; Belongs to the integrin beta chain family.
    
 0.953
RUNX2
Runt-related transcription factor 2; Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. Inhibits KAT6B-dependent transcriptional activation. In osteoblasts, supports transcription activati [...]
     
 0.918
MMP7
Matrix metallopeptidase 7.
   
 
 0.908
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.