METAP1 protein (Equus caballus) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

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METAP1

Methionine aminopeptidase; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). (526 aa)

Predicted Functional Partners:

METAP2

0.910

RPL5

0.886

HBS1L

0.874

QARS1

0.866

RPL23

0.865

RPS18

0.851

RPL17-C18orf32

0.850

RPS11

0.847

RPL38

0.837

F7C9N2_HORSE

0.832

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F7C9N2_HORSE	HBS1L	ENSECAP00000000759	ENSECAP00000032432	Uncharacterized protein.	HBS1 like translational GTPase.	0.607
F7C9N2_HORSE	METAP1	ENSECAP00000000759	ENSECAP00000015494	Uncharacterized protein.	Methionine aminopeptidase; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val).	0.832
F7C9N2_HORSE	METAP2	ENSECAP00000000759	ENSECAP00000036764	Uncharacterized protein.	Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.	0.831
F7C9N2_HORSE	QARS1	ENSECAP00000000759	ENSECAP00000002874	Uncharacterized protein.	Glutaminyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.821
F7C9N2_HORSE	RPL17-C18orf32	ENSECAP00000000759	ENSECAP00000031560	Uncharacterized protein.	RPL17-C18orf32 readthrough; Belongs to the universal ribosomal protein uL22 family.	0.989
F7C9N2_HORSE	RPL23	ENSECAP00000000759	ENSECAP00000038347	Uncharacterized protein.	Ribosomal protein L23; Belongs to the universal ribosomal protein uL14 family.	0.990
F7C9N2_HORSE	RPL38	ENSECAP00000000759	ENSECAP00000016109	Uncharacterized protein.	Uncharacterized protein; Belongs to the eukaryotic ribosomal protein eL38 family.	0.900
F7C9N2_HORSE	RPL5	ENSECAP00000000759	ENSECAP00000018699	Uncharacterized protein.	Ribosomal protein L5.	0.990
F7C9N2_HORSE	RPS11	ENSECAP00000000759	ENSECAP00000000228	Uncharacterized protein.	Ribosomal protein S11; Belongs to the universal ribosomal protein uS17 family.	0.997
F7C9N2_HORSE	RPS18	ENSECAP00000000759	ENSECAP00000013663	Uncharacterized protein.	Ribosomal protein S18; Belongs to the universal ribosomal protein uS13 family.	0.997
HBS1L	F7C9N2_HORSE	ENSECAP00000032432	ENSECAP00000000759	HBS1 like translational GTPase.	Uncharacterized protein.	0.607
HBS1L	METAP1	ENSECAP00000032432	ENSECAP00000015494	HBS1 like translational GTPase.	Methionine aminopeptidase; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val).	0.874
HBS1L	QARS1	ENSECAP00000032432	ENSECAP00000002874	HBS1 like translational GTPase.	Glutaminyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.826
HBS1L	RPL17-C18orf32	ENSECAP00000032432	ENSECAP00000031560	HBS1 like translational GTPase.	RPL17-C18orf32 readthrough; Belongs to the universal ribosomal protein uL22 family.	0.760
HBS1L	RPL23	ENSECAP00000032432	ENSECAP00000038347	HBS1 like translational GTPase.	Ribosomal protein L23; Belongs to the universal ribosomal protein uL14 family.	0.774
HBS1L	RPL38	ENSECAP00000032432	ENSECAP00000016109	HBS1 like translational GTPase.	Uncharacterized protein; Belongs to the eukaryotic ribosomal protein eL38 family.	0.829
HBS1L	RPL5	ENSECAP00000032432	ENSECAP00000018699	HBS1 like translational GTPase.	Ribosomal protein L5.	0.775
HBS1L	RPS11	ENSECAP00000032432	ENSECAP00000000228	HBS1 like translational GTPase.	Ribosomal protein S11; Belongs to the universal ribosomal protein uS17 family.	0.774
HBS1L	RPS18	ENSECAP00000032432	ENSECAP00000013663	HBS1 like translational GTPase.	Ribosomal protein S18; Belongs to the universal ribosomal protein uS13 family.	0.789
METAP1	F7C9N2_HORSE	ENSECAP00000015494	ENSECAP00000000759	Methionine aminopeptidase; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val).	Uncharacterized protein.	0.832

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Network Stats

number of nodes:

11

number of edges:

43

average node degree:

7.82

avg. local clustering coefficient:

0.927

expected number of edges:

11

PPI enrichment p-value:

1.65e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006032

Chitin catabolic process

3 of 46

2.17

1.91

0.0013

GO:0005975

Carbohydrate metabolic process

5 of 391

1.47

1.67

0.00017

GO:0000272

Polysaccharide catabolic process

3 of 132

1.72

1.37

0.0051

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004553

Hydrolase activity, hydrolyzing O-glycosyl compounds

5 of 189

1.78

2.82

2.09e-06

GO:0004568

Chitinase activity

3 of 38

2.26

2.41

0.00022

GO:0008061

Chitin binding

3 of 49

2.15

2.24

0.00034

GO:0102148

N-acetyl-beta-D-galactosaminidase activity

2 of 8

2.76

1.89

0.0022

GO:0004563

beta-N-acetylhexosaminidase activity

2 of 8

2.76

1.89

0.0022

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005576

Extracellular region

5 of 432

1.42

1.7

6.50e-05

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:21184821

(2011) Inhibition of 2,4-dinitrofluorobenzene-induced atopic dermatitis by topical application of the butanol extract of Cordyceps bassiana in NCNga mice.

2 of 7

2.82

2.05

0.0013

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:16527

Glycosyl hydrolases family 18, and beta-Lactam resistance

5 of 15

2.88

7.31

1.73e-11

CL:16544

Glycosyl hydrolases family 18

3 of 6

3.06

4.43

5.55e-07

CL:16530

beta-Lactam resistance, and Beta-acetyl hexosaminidase like

2 of 5

2.96

2.36

0.00049

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00520

Amino sugar and nucleotide sugar metabolism

5 of 177

1.81

3.25

1.49e-07

map00604

Glycosphingolipid biosynthesis - ganglio series

2 of 13

2.55

2.04

0.0012

map00603

Glycosphingolipid biosynthesis - globo and isoglobo series

2 of 19

2.38

1.92

0.0016

map00511

Other glycan degradation

2 of 22

2.32

1.9

0.0016

map00531

Glycosaminoglycan degradation

2 of 29

2.2

1.78

0.0022

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2160916

Hyaluronan uptake and degradation

2 of 9

2.71

1.56

0.0065

MAP-2024101

CS/DS degradation

2 of 8

2.76

1.56

0.0065

MAP-1793185

Chondroitin sulfate/dermatan sulfate metabolism

2 of 8

2.76

1.56

0.0065

MAP-2022857

Keratan sulfate degradation

2 of 13

2.55

1.54

0.0065

MAP-1638074

Keratan sulfate/keratin metabolism

2 of 13

2.55

1.54

0.0065

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009277

Fungal-type cell wall

3 of 48

2.16

2.03

0.00081

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0326

Glycosidase

4 of 72

2.1

3.37

2.15e-06

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00704

Glycosyl hydrolases family 18

3 of 13

2.72

3.23

2.32e-05

PF14845

Beta-acetyl hexosaminidase like

2 of 3

3.18

2.23

0.00079

PF00728

Glycosyl hydrolase family 20, catalytic domain

2 of 9

2.71

1.8

0.0029

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR017853

Glycoside hydrolase superfamily

5 of 117

1.99

3.53

3.60e-07

IPR001223

Glycoside hydrolase family 18, catalytic domain

3 of 29

2.37

2.4

0.00028

IPR029019

Beta-hexosaminidase, eukaryotic type, N-terminal

2 of 3

3.18

2.05

0.0014

IPR025705

Beta-hexosaminidase

2 of 9

2.71

1.58

0.0060

IPR015883

Glycoside hydrolase family 20, catalytic domain

2 of 9

2.71

1.58

0.0060

(more ...)

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