STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CTSKCathepsin K; Belongs to the peptidase C1 family. (329 aa)    
Predicted Functional Partners:
BID
BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.
   
 
 0.925
BCL2L1
BCL2 like 1.
   
 
 0.904
NFATC1
Nuclear factor of activated T cells 1.
   
  
 0.834
DCSTAMP
Dendrocyte expressed seven transmembrane protein.
      
 0.787
CALCR
Calcitonin receptor; Belongs to the G-protein coupled receptor 2 family.
   
  
 0.785
MMP13
Collagenase 3; Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bon [...]
   
 
 0.730
OCSTAMP
Osteoclast stimulatory transmembrane protein.
   
  
 0.710
MMP9
Matrix metallopeptidase 9.
   
 0.707
LOC100051301
SERPIN domain-containing protein; Belongs to the serpin family.
    
 0.690
SOST
Sclerostin.
   
 
 0.688
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.