ARL4A protein (Equus caballus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ARL4A

ADP-ribosylation factor-like protein 4A-like protein. (200 aa)

Predicted Functional Partners:

ANKRD16

0.871

NSMCE4A

0.854

TMEM14C

0.851

ITSN2

0.825

ITSN1

0.723

GGA1

0.677

GAK

0.658

CCDC12

0.650

CYTH2

0.577

GBF1

0.573

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD16	ARL4A	ENSECAP00000017683	ENSECAP00000016780	Ankyrin repeat domain 16.	ADP-ribosylation factor-like protein 4A-like protein.	0.871
ANKRD16	CCDC12	ENSECAP00000017683	ENSECAP00000006608	Ankyrin repeat domain 16.	Coiled-coil domain containing 12.	0.758
ANKRD16	GGA1	ENSECAP00000017683	ENSECAP00000027939	Ankyrin repeat domain 16.	Golgi associated, gamma adaptin ear containing, ARF binding protein 1.	0.714
ANKRD16	NSMCE4A	ENSECAP00000017683	ENSECAP00000014399	Ankyrin repeat domain 16.	Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.	0.825
ANKRD16	TMEM14C	ENSECAP00000017683	ENSECAP00000022757	Ankyrin repeat domain 16.	Transmembrane protein 14C.	0.801
ARL4A	ANKRD16	ENSECAP00000016780	ENSECAP00000017683	ADP-ribosylation factor-like protein 4A-like protein.	Ankyrin repeat domain 16.	0.871
ARL4A	CCDC12	ENSECAP00000016780	ENSECAP00000006608	ADP-ribosylation factor-like protein 4A-like protein.	Coiled-coil domain containing 12.	0.650
ARL4A	CYTH2	ENSECAP00000016780	ENSECAP00000035380	ADP-ribosylation factor-like protein 4A-like protein.	Cytohesin 2.	0.577
ARL4A	GAK	ENSECAP00000016780	ENSECAP00000021630	ADP-ribosylation factor-like protein 4A-like protein.	Cyclin G associated kinase.	0.658
ARL4A	GBF1	ENSECAP00000016780	ENSECAP00000044820	ADP-ribosylation factor-like protein 4A-like protein.	Golgi brefeldin A resistant guanine nucleotide exchange factor 1.	0.573
ARL4A	GGA1	ENSECAP00000016780	ENSECAP00000027939	ADP-ribosylation factor-like protein 4A-like protein.	Golgi associated, gamma adaptin ear containing, ARF binding protein 1.	0.677
ARL4A	ITSN1	ENSECAP00000016780	ENSECAP00000011417	ADP-ribosylation factor-like protein 4A-like protein.	Intersectin 1.	0.723
ARL4A	ITSN2	ENSECAP00000016780	ENSECAP00000023079	ADP-ribosylation factor-like protein 4A-like protein.	Intersectin 2.	0.825
ARL4A	NSMCE4A	ENSECAP00000016780	ENSECAP00000014399	ADP-ribosylation factor-like protein 4A-like protein.	Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.	0.854
ARL4A	TMEM14C	ENSECAP00000016780	ENSECAP00000022757	ADP-ribosylation factor-like protein 4A-like protein.	Transmembrane protein 14C.	0.851
CCDC12	ANKRD16	ENSECAP00000006608	ENSECAP00000017683	Coiled-coil domain containing 12.	Ankyrin repeat domain 16.	0.758
CCDC12	ARL4A	ENSECAP00000006608	ENSECAP00000016780	Coiled-coil domain containing 12.	ADP-ribosylation factor-like protein 4A-like protein.	0.650
CCDC12	NSMCE4A	ENSECAP00000006608	ENSECAP00000014399	Coiled-coil domain containing 12.	Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.	0.562
CCDC12	TMEM14C	ENSECAP00000006608	ENSECAP00000022757	Coiled-coil domain containing 12.	Transmembrane protein 14C.	0.547
CYTH2	ARL4A	ENSECAP00000035380	ENSECAP00000016780	Cytohesin 2.	ADP-ribosylation factor-like protein 4A-like protein.	0.577

page 1 of 3

Network Stats

number of nodes:

4

number of edges:

4

average node degree:

2

avg. local clustering coefficient:

0.833

expected number of edges:

3

PPI enrichment p-value:

0.414

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0060070

Canonical Wnt signaling pathway

3 of 81

1.9

0.9

0.0189

GO:0016055

Wnt signaling pathway

4 of 216

1.6

0.85

0.0185

GO:0090090

Negative regulation of canonical Wnt signaling pathway

3 of 98

1.82

0.83

0.0247

GO:0046849

Bone remodeling

2 of 14

2.49

0.83

0.0304

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0071936

Coreceptor activity involved in Wnt signaling pathway

2 of 2

3.33

1.39

0.0031

GO:0039706

Co-receptor binding

2 of 7

2.79

1.12

0.0094

GO:0048019

Receptor antagonist activity

2 of 9

2.68

1.11

0.0095

GO:0042813

Wnt receptor activity

2 of 18

2.38

0.93

0.0197

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0071821

FANCM-MHF complex

2 of 5

2.93

1.26

0.0052

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:37339990

(2023) TGFbeta inhibition and mesenchymal to epithelial transition initiation by Xenopus egg extract: first steps towards early reprogramming in fish somatic cell.

3 of 42

2.19

1.18

0.0061

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:21213

Negative regulation of TCF-dependent signaling by WNT ligand antagonists

4 of 6

3.16

4.15

2.70e-08

CL:21106

Wnt signaling pathway, and Negative regulation of TCF-dependent signaling by WNT ligand antagonists

5 of 61

2.25

3.36

1.69e-07

CL:1161

Mixed, incl. Centromere complex assembly, and Carbohydrate-binding WSC

2 of 16

2.43

0.94

0.0190

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ola04310

Wnt signaling pathway

3 of 180

1.55

0.91

0.0120

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-3772470

Negative regulation of TCF-dependent signaling by WNT ligand antagonists

5 of 12

2.95

5.44

7.75e-11

MAP-201681

TCF dependent signaling in response to WNT

5 of 258

1.62

1.77

6.00e-05

MAP-195721

Signaling by WNT

5 of 413

1.41

1.33

0.00040

MAP-4641263

Regulation of FZD by ubiquitination

2 of 22

2.29

0.95

0.0180

MAP-162582

Signal Transduction

9 of 4038

0.68

0.53

0.0021

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990851

Wnt-Frizzled-LRP5/6 complex

2 of 2

3.33

1.53

0.0018

GOCC:0071821

FANCM-MHF complex

2 of 5

2.93

1.52

0.0018

GOCC:0098797

Plasma membrane protein complex

5 of 479

1.35

1.09

0.0018

GOCC:0098796

Membrane protein complex

6 of 1010

1.11

0.9

0.0018

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01822

WSC domain

2 of 2

3.33

1.43

0.0027

PF04706

Dickkopf N-terminal cysteine-rich region

2 of 6

2.85

1.22

0.0063

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR002889

Carbohydrate-binding WSC

3 of 3

3.33

2.75

1.08e-05

IPR039863

Dickkopf-like protein

2 of 6

2.85

0.94

0.0198

IPR006796

Dickkopf, N-terminal cysteine-rich

2 of 6

2.85

0.94

0.0198

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (26%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About