NLRP2 protein (Equus caballus) - STRING interaction network

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Score

NLRP2

NLR family pyrin domain containing 2. (1076 aa)

Predicted Functional Partners:

NLRC4

0.735

KLHDC10

0.679

PYCARD

0.655

PADI3

0.586

CASP1

0.582

NLRP1

0.556

MEFV

0.542

ZDBF2

0.524

GRHL1

0.516

LILRA

0.511

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP1	MEFV	ENSECAP00000021890	ENSECAP00000005035	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	MEFV innate immuity regulator, pyrin.	0.991
CASP1	NLRC4	ENSECAP00000021890	ENSECAP00000017295	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	NLR family CARD domain containing 4.	0.997
CASP1	NLRP1	ENSECAP00000021890	ENSECAP00000006832	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	NLR family pyrin domain containing 1.	0.975
CASP1	NLRP2	ENSECAP00000021890	ENSECAP00000017692	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	NLR family pyrin domain containing 2.	0.582
CASP1	PYCARD	ENSECAP00000021890	ENSECAP00000008035	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	PYD and CARD domain containing.	0.977
GRHL1	NLRP2	ENSECAP00000033228	ENSECAP00000017692	Grainyhead like transcription factor 1.	NLR family pyrin domain containing 2.	0.516
KLHDC10	NLRP2	ENSECAP00000054782	ENSECAP00000017692	Kelch domain containing 10.	NLR family pyrin domain containing 2.	0.679
KLHDC10	ZDBF2	ENSECAP00000054782	ENSECAP00000024820	Kelch domain containing 10.	Zinc finger DBF-type containing 2.	0.403
LILRA	NLRP2	ENSECAP00000011769	ENSECAP00000017692	Ig-like domain-containing protein.	NLR family pyrin domain containing 2.	0.511
MEFV	CASP1	ENSECAP00000005035	ENSECAP00000021890	MEFV innate immuity regulator, pyrin.	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	0.991
MEFV	NLRC4	ENSECAP00000005035	ENSECAP00000017295	MEFV innate immuity regulator, pyrin.	NLR family CARD domain containing 4.	0.858
MEFV	NLRP1	ENSECAP00000005035	ENSECAP00000006832	MEFV innate immuity regulator, pyrin.	NLR family pyrin domain containing 1.	0.846
MEFV	NLRP2	ENSECAP00000005035	ENSECAP00000017692	MEFV innate immuity regulator, pyrin.	NLR family pyrin domain containing 2.	0.542
MEFV	PYCARD	ENSECAP00000005035	ENSECAP00000008035	MEFV innate immuity regulator, pyrin.	PYD and CARD domain containing.	0.717
NLRC4	CASP1	ENSECAP00000017295	ENSECAP00000021890	NLR family CARD domain containing 4.	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	0.997
NLRC4	MEFV	ENSECAP00000017295	ENSECAP00000005035	NLR family CARD domain containing 4.	MEFV innate immuity regulator, pyrin.	0.858
NLRC4	NLRP1	ENSECAP00000017295	ENSECAP00000006832	NLR family CARD domain containing 4.	NLR family pyrin domain containing 1.	0.997
NLRC4	NLRP2	ENSECAP00000017295	ENSECAP00000017692	NLR family CARD domain containing 4.	NLR family pyrin domain containing 2.	0.735
NLRC4	PYCARD	ENSECAP00000017295	ENSECAP00000008035	NLR family CARD domain containing 4.	PYD and CARD domain containing.	0.862
NLRP1	CASP1	ENSECAP00000006832	ENSECAP00000021890	NLR family pyrin domain containing 1.	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	0.975