node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACAN | COL3A1 | ENSECAP00000038831 | ENSECAP00000022362 | Aggrecan. | Collagen type III alpha 1 chain. | 0.525 |
ACAN | DCN | ENSECAP00000038831 | ENSECAP00000017861 | Aggrecan. | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | 0.955 |
ACAN | IGF1 | ENSECAP00000038831 | ENSECAP00000033255 | Aggrecan. | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] | 0.685 |
ACAN | LUM | ENSECAP00000038831 | ENSECAP00000015833 | Aggrecan. | Lumican. | 0.865 |
ACAN | TGFB1 | ENSECAP00000038831 | ENSECAP00000009480 | Aggrecan. | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] | 0.794 |
COL3A1 | ACAN | ENSECAP00000022362 | ENSECAP00000038831 | Collagen type III alpha 1 chain. | Aggrecan. | 0.525 |
COL3A1 | DCN | ENSECAP00000022362 | ENSECAP00000017861 | Collagen type III alpha 1 chain. | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | 0.955 |
COL3A1 | IGF1 | ENSECAP00000022362 | ENSECAP00000033255 | Collagen type III alpha 1 chain. | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] | 0.413 |
COL3A1 | LUM | ENSECAP00000022362 | ENSECAP00000015833 | Collagen type III alpha 1 chain. | Lumican. | 0.924 |
COL3A1 | TGFB1 | ENSECAP00000022362 | ENSECAP00000009480 | Collagen type III alpha 1 chain. | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] | 0.709 |
COL3A1 | TGFB2 | ENSECAP00000022362 | ENSECAP00000051244 | Collagen type III alpha 1 chain. | Transforming growth factor beta; Belongs to the TGF-beta family. | 0.466 |
DCN | ACAN | ENSECAP00000017861 | ENSECAP00000038831 | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | Aggrecan. | 0.955 |
DCN | COL3A1 | ENSECAP00000017861 | ENSECAP00000022362 | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | Collagen type III alpha 1 chain. | 0.955 |
DCN | EGFR | ENSECAP00000017861 | ENSECAP00000035347 | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | Receptor protein-tyrosine kinase. | 0.964 |
DCN | IGF1 | ENSECAP00000017861 | ENSECAP00000033255 | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] | 0.969 |
DCN | LUM | ENSECAP00000017861 | ENSECAP00000015833 | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | Lumican. | 0.945 |
DCN | MET | ENSECAP00000017861 | ENSECAP00000008993 | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | 0.954 |
DCN | TGFB1 | ENSECAP00000017861 | ENSECAP00000009480 | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] | 0.991 |
DCN | TGFB2 | ENSECAP00000017861 | ENSECAP00000051244 | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | Transforming growth factor beta; Belongs to the TGF-beta family. | 0.949 |
DCN | TLR2 | ENSECAP00000017861 | ENSECAP00000015544 | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] | 0.947 |