CSNK2B protein (Equus caballus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

CSNK2B

Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (235 aa)

Predicted Functional Partners:

CSNK2A2

0.991

CSNK2A1

0.988

DVL2

0.936

DVL3

0.936

DVL1

0.934

PTEN

0.933

NFKBIA

0.913

CTNNB1

0.911

PRNP

0.907

LY6G5B

0.900

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSNK2A1	CSNK2A2	ENSECAP00000044606	ENSECAP00000011977	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily.	0.990
CSNK2A1	CSNK2B	ENSECAP00000044606	ENSECAP00000018636	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family.	0.988
CSNK2A1	CTNNB1	ENSECAP00000044606	ENSECAP00000005466	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Beta catenin 1.	0.923
CSNK2A1	DVL1	ENSECAP00000044606	ENSECAP00000018472	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Dishevelled segment polarity protein 1.	0.947
CSNK2A1	DVL2	ENSECAP00000044606	ENSECAP00000003038	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Dishevelled segment polarity protein 2.	0.943
CSNK2A1	DVL3	ENSECAP00000044606	ENSECAP00000007449	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Dishevelled segment polarity protein 3.	0.943
CSNK2A1	LY6G5B	ENSECAP00000044606	ENSECAP00000006432	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Lymphocyte antigen 6 family member G5B.	0.917
CSNK2A1	NFKBIA	ENSECAP00000044606	ENSECAP00000020980	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	NFKB inhibitor alpha.	0.910
CSNK2A1	PRNP	ENSECAP00000044606	ENSECAP00000031540	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Major prion protein; Belongs to the prion family.	0.909
CSNK2A1	PTEN	ENSECAP00000044606	ENSECAP00000014788	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Phosphatase and tensin homolog.	0.944
CSNK2A2	CSNK2A1	ENSECAP00000011977	ENSECAP00000044606	Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.990
CSNK2A2	CSNK2B	ENSECAP00000011977	ENSECAP00000018636	Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily.	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family.	0.991
CSNK2A2	CTNNB1	ENSECAP00000011977	ENSECAP00000005466	Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily.	Beta catenin 1.	0.923
CSNK2A2	DVL1	ENSECAP00000011977	ENSECAP00000018472	Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily.	Dishevelled segment polarity protein 1.	0.947
CSNK2A2	DVL2	ENSECAP00000011977	ENSECAP00000003038	Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily.	Dishevelled segment polarity protein 2.	0.953
CSNK2A2	DVL3	ENSECAP00000011977	ENSECAP00000007449	Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily.	Dishevelled segment polarity protein 3.	0.943
CSNK2A2	LY6G5B	ENSECAP00000011977	ENSECAP00000006432	Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily.	Lymphocyte antigen 6 family member G5B.	0.916
CSNK2A2	NFKBIA	ENSECAP00000011977	ENSECAP00000020980	Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily.	NFKB inhibitor alpha.	0.912
CSNK2A2	PRNP	ENSECAP00000011977	ENSECAP00000031540	Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily.	Major prion protein; Belongs to the prion family.	0.909
CSNK2A2	PTEN	ENSECAP00000011977	ENSECAP00000014788	Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily.	Phosphatase and tensin homolog.	0.944

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.982

expected number of edges:

12

PPI enrichment p-value:

7.52e-14

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0097588

Archaeal or bacterial-type flagellum-dependent cell motility

5 of 19

1.72

1.91

4.38e-05

GO:0044781

Bacterial-type flagellum organization

4 of 12

1.82

1.8

0.00015

GO:0071973

Bacterial-type flagellum-dependent cell motility

4 of 17

1.67

1.57

0.00032

GO:0006935

Chemotaxis

3 of 19

1.5

0.83

0.0171

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003774

Cytoskeletal motor activity

4 of 7

2.06

2.12

5.53e-05

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009288

Bacterial-type flagellum

6 of 23

1.72

2.66

1.50e-07

GO:0009425

Bacterial-type flagellum basal body

4 of 18

1.65

1.74

8.87e-05

GO:0009424

Bacterial-type flagellum hook

2 of 3

2.12

1.25

0.0043

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2053

Flagellar assembly

11 of 26

1.93

5.82

2.94e-18

CL:2054

Flagellar assembly

10 of 21

1.98

5.77

8.31e-17

CL:2057

Bacterial-type flagellum basal body, and Bacterial flagellum protein export

4 of 14

1.76

1.98

3.60e-05

CL:2060

Bacterial-type flagellum-dependent cell motility

2 of 5

1.9

0.93

0.0159

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02040

Flagellar assembly

9 of 33

1.74

3.91

7.48e-13

map02030

Bacterial chemotaxis

3 of 28

1.33

0.75

0.0203

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009288

Bacterial-type flagellum

6 of 29

1.62

2.28

9.00e-07

GOCC:0009425

Bacterial-type flagellum basal body

4 of 16

1.7

1.75

0.00011

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0282

Flagellum

9 of 32

1.75

3.94

1.01e-12

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (24%) [HD]

Permalink

Network

Fusion

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Neighborhood

© STRING Consortium 2024

Credits

Access

Info

About