ATP8B1 protein (Equus caballus) - STRING interaction network

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Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

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gene co-occurrence

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protein homology

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ATP8B1

Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1251 aa)

Predicted Functional Partners:

ANO8

0.810

ABCB11

0.742

RPH3AL

0.679

TJP2

0.671

LOC100072302

0.664

TMEM30A

0.664

LDLRAP1

0.626

ATP7A

0.589

AMIGO2

0.542

C10orf71

0.513

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCB11	ANO8	ENSECAP00000013242	ENSECAP00000012042	ATP binding cassette subfamily B member 11.	Anoctamin.	0.700
ABCB11	ATP8B1	ENSECAP00000013242	ENSECAP00000018921	ATP binding cassette subfamily B member 11.	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	0.742
ABCB11	C10orf71	ENSECAP00000013242	ENSECAP00000002742	ATP binding cassette subfamily B member 11.	Chromosome 10 open reading frame 71.	0.436
ABCB11	TJP2	ENSECAP00000013242	ENSECAP00000014912	ATP binding cassette subfamily B member 11.	Tight junction protein 2; Belongs to the MAGUK family.	0.517
AMIGO2	ATP8B1	ENSECAP00000017296	ENSECAP00000018921	Adhesion molecule with Ig like domain 2.	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	0.542
AMIGO2	LDLRAP1	ENSECAP00000017296	ENSECAP00000017034	Adhesion molecule with Ig like domain 2.	Low density lipoprotein receptor adaptor protein 1.	0.572
AMIGO2	RPH3AL	ENSECAP00000017296	ENSECAP00000029949	Adhesion molecule with Ig like domain 2.	Rabphilin 3A like (without C2 domains).	0.676
ANO8	ABCB11	ENSECAP00000012042	ENSECAP00000013242	Anoctamin.	ATP binding cassette subfamily B member 11.	0.700
ANO8	ATP8B1	ENSECAP00000012042	ENSECAP00000018921	Anoctamin.	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	0.810
ANO8	C10orf71	ENSECAP00000012042	ENSECAP00000002742	Anoctamin.	Chromosome 10 open reading frame 71.	0.864
ANO8	TJP2	ENSECAP00000012042	ENSECAP00000014912	Anoctamin.	Tight junction protein 2; Belongs to the MAGUK family.	0.693
ATP7A	ATP8B1	ENSECAP00000015148	ENSECAP00000018921	ATPase copper transporting alpha.	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	0.589
ATP8B1	ABCB11	ENSECAP00000018921	ENSECAP00000013242	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	ATP binding cassette subfamily B member 11.	0.742
ATP8B1	AMIGO2	ENSECAP00000018921	ENSECAP00000017296	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	Adhesion molecule with Ig like domain 2.	0.542
ATP8B1	ANO8	ENSECAP00000018921	ENSECAP00000012042	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	Anoctamin.	0.810
ATP8B1	ATP7A	ENSECAP00000018921	ENSECAP00000015148	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	ATPase copper transporting alpha.	0.589
ATP8B1	C10orf71	ENSECAP00000018921	ENSECAP00000002742	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	Chromosome 10 open reading frame 71.	0.513
ATP8B1	LDLRAP1	ENSECAP00000018921	ENSECAP00000017034	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	Low density lipoprotein receptor adaptor protein 1.	0.626
ATP8B1	LOC100072302	ENSECAP00000018921	ENSECAP00000012074	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	Cell cycle control protein; Belongs to the CDC50/LEM3 family.	0.664
ATP8B1	RPH3AL	ENSECAP00000018921	ENSECAP00000029949	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	Rabphilin 3A like (without C2 domains).	0.679

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Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

47

PPI enrichment p-value:

0.0318

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

11 of 309

1.77

4.66

3.02e-16

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

10 of 155

2.03

6.04

7.21e-17

GO:0019843

rRNA binding

4 of 43

2.19

2.52

1.03e-05

GO:0003723

RNA binding

6 of 1039

0.98

0.69

0.0076

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

10 of 177

1.97

5.71

1.28e-16

GO:0044391

Ribosomal subunit

7 of 130

1.95

3.98

2.21e-10

GO:0015935

Small ribosomal subunit

4 of 48

2.14

2.6

5.79e-06

GO:0022626

Cytosolic ribosome

4 of 52

2.11

2.56

6.27e-06

GO:0015934

Large ribosomal subunit

3 of 81

1.79

1.29

0.0023

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:14887

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

10 of 101

2.22

7.32

1.83e-18

CL:14896

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

9 of 90

2.22

6.89

5.10e-17

CL:14897

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

7 of 78

2.18

5.13

3.18e-12

CL:14902

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

6 of 69

2.16

4.31

4.44e-10

CL:14907

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

4 of 45

2.17

2.72

3.52e-06

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03010

Ribosome

10 of 176

1.98

5.91

1.90e-17

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72706

GTP hydrolysis and joining of the 60S ribosomal subunit

8 of 108

2.09

5.17

5.36e-13

MAP-72737

Cap-dependent Translation Initiation

8 of 124

2.03

4.94

7.74e-13

MAP-72613

Eukaryotic Translation Initiation

8 of 124

2.03

4.94

7.74e-13

MAP-975956

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

7 of 94

2.09

4.68

1.66e-11

MAP-72689

Formation of a pool of free 40S subunits

7 of 98

2.08

4.63

1.75e-11

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0022626

Cytosolic ribosome

6 of 51

2.29

4.51

4.67e-10

GOCC:0022627

Cytosolic small ribosomal subunit

5 of 25

2.52

4.4

2.82e-09

GOCC:1990904

Ribonucleoprotein complex

6 of 402

1.4

1.66

1.22e-05

GOCC:0043232

Intracellular non-membrane-bounded organelle

7 of 1957

0.78

0.55

0.0066

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

5 of 59

2.15

3.44

6.54e-08

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04758

Ribosomal protein S30

3 of 3

3.22

2.86

6.73e-06

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006846

Ribosomal protein S30

2 of 2

3.22

1.05

0.0130

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