node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BMT2 | C6H12orf66 | ENSECAP00000019141 | ENSECAP00000013751 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | Chromosome 6 C12orf66 homolog. | 0.885 |
BMT2 | DEPDC5 | ENSECAP00000019141 | ENSECAP00000012891 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | DEP domain containing 5. | 0.884 |
BMT2 | ITFG2 | ENSECAP00000019141 | ENSECAP00000046880 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | Integrin alpha FG-GAP repeat containing 2. | 0.856 |
BMT2 | KPTN | ENSECAP00000019141 | ENSECAP00000016079 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | Kaptin, actin binding protein. | 0.856 |
BMT2 | MLST8 | ENSECAP00000019141 | ENSECAP00000006738 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | MTOR associated protein, LST8 homolog. | 0.773 |
BMT2 | NPRL2 | ENSECAP00000019141 | ENSECAP00000020173 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | NPR2 like, GATOR1 complex subunit. | 0.783 |
BMT2 | NPRL3 | ENSECAP00000019141 | ENSECAP00000044559 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | NPR3 like, GATOR1 complex subunit. | 0.815 |
BMT2 | SESN2 | ENSECAP00000019141 | ENSECAP00000002571 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | Sestrin 2. | 0.742 |
BMT2 | SLC39A9 | ENSECAP00000019141 | ENSECAP00000017946 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | Solute carrier family 39 member 9. | 0.901 |
BMT2 | SZT2 | ENSECAP00000019141 | ENSECAP00000010076 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | SZT2 subunit of KICSTOR complex. | 0.827 |
C6H12orf66 | BMT2 | ENSECAP00000013751 | ENSECAP00000019141 | Chromosome 6 C12orf66 homolog. | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | 0.885 |
C6H12orf66 | DEPDC5 | ENSECAP00000013751 | ENSECAP00000012891 | Chromosome 6 C12orf66 homolog. | DEP domain containing 5. | 0.993 |
C6H12orf66 | ITFG2 | ENSECAP00000013751 | ENSECAP00000046880 | Chromosome 6 C12orf66 homolog. | Integrin alpha FG-GAP repeat containing 2. | 0.999 |
C6H12orf66 | KPTN | ENSECAP00000013751 | ENSECAP00000016079 | Chromosome 6 C12orf66 homolog. | Kaptin, actin binding protein. | 0.998 |
C6H12orf66 | MLST8 | ENSECAP00000013751 | ENSECAP00000006738 | Chromosome 6 C12orf66 homolog. | MTOR associated protein, LST8 homolog. | 0.432 |
C6H12orf66 | NPRL2 | ENSECAP00000013751 | ENSECAP00000020173 | Chromosome 6 C12orf66 homolog. | NPR2 like, GATOR1 complex subunit. | 0.990 |
C6H12orf66 | NPRL3 | ENSECAP00000013751 | ENSECAP00000044559 | Chromosome 6 C12orf66 homolog. | NPR3 like, GATOR1 complex subunit. | 0.850 |
C6H12orf66 | SESN2 | ENSECAP00000013751 | ENSECAP00000002571 | Chromosome 6 C12orf66 homolog. | Sestrin 2. | 0.525 |
C6H12orf66 | SZT2 | ENSECAP00000013751 | ENSECAP00000010076 | Chromosome 6 C12orf66 homolog. | SZT2 subunit of KICSTOR complex. | 0.992 |
DEPDC5 | BMT2 | ENSECAP00000012891 | ENSECAP00000019141 | DEP domain containing 5. | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | 0.884 |