RACK1 protein (Equus caballus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

RACK1

WD_REPEATS_REGION domain-containing protein. (317 aa)

Predicted Functional Partners:

RPS16

0.998

RPL8

0.998

RPS20

0.998

RPS8

0.998

RPS5

0.998

RPS9

0.998

RPL5

0.998

RPL4

0.998

RPS26

0.998

RPS23

0.998

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
RACK1	RPL4	ENSECAP00000019998	ENSECAP00000020849	WD_REPEATS_REGION domain-containing protein.	Ribosomal protein L4.	0.998
RACK1	RPL5	ENSECAP00000019998	ENSECAP00000018699	WD_REPEATS_REGION domain-containing protein.	Ribosomal protein L5.	0.998
RACK1	RPL8	ENSECAP00000019998	ENSECAP00000006504	WD_REPEATS_REGION domain-containing protein.	Ribosomal protein L8.	0.998
RACK1	RPS16	ENSECAP00000019998	ENSECAP00000003502	WD_REPEATS_REGION domain-containing protein.	Ribosomal protein S16; Belongs to the universal ribosomal protein uS9 family.	0.998
RACK1	RPS20	ENSECAP00000019998	ENSECAP00000010187	WD_REPEATS_REGION domain-containing protein.	Ribosomal protein S20.	0.998
RACK1	RPS23	ENSECAP00000019998	ENSECAP00000023304	WD_REPEATS_REGION domain-containing protein.	Ribosomal protein S23; Belongs to the universal ribosomal protein uS12 family.	0.998
RACK1	RPS26	ENSECAP00000019998	ENSECAP00000021737	WD_REPEATS_REGION domain-containing protein.	40S ribosomal protein S26; Belongs to the eukaryotic ribosomal protein eS26 family.	0.998
RACK1	RPS5	ENSECAP00000019998	ENSECAP00000013879	WD_REPEATS_REGION domain-containing protein.	Ribosomal protein S5; Belongs to the universal ribosomal protein uS7 family.	0.998
RACK1	RPS8	ENSECAP00000019998	ENSECAP00000012814	WD_REPEATS_REGION domain-containing protein.	40S ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family.	0.998
RACK1	RPS9	ENSECAP00000019998	ENSECAP00000017862	WD_REPEATS_REGION domain-containing protein.	Ribosomal protein S9; Belongs to the universal ribosomal protein uS4 family.	0.998
RPL4	RACK1	ENSECAP00000020849	ENSECAP00000019998	Ribosomal protein L4.	WD_REPEATS_REGION domain-containing protein.	0.998
RPL4	RPL5	ENSECAP00000020849	ENSECAP00000018699	Ribosomal protein L4.	Ribosomal protein L5.	0.999
RPL4	RPL8	ENSECAP00000020849	ENSECAP00000006504	Ribosomal protein L4.	Ribosomal protein L8.	0.999
RPL4	RPS16	ENSECAP00000020849	ENSECAP00000003502	Ribosomal protein L4.	Ribosomal protein S16; Belongs to the universal ribosomal protein uS9 family.	0.999
RPL4	RPS20	ENSECAP00000020849	ENSECAP00000010187	Ribosomal protein L4.	Ribosomal protein S20.	0.999
RPL4	RPS23	ENSECAP00000020849	ENSECAP00000023304	Ribosomal protein L4.	Ribosomal protein S23; Belongs to the universal ribosomal protein uS12 family.	0.999
RPL4	RPS26	ENSECAP00000020849	ENSECAP00000021737	Ribosomal protein L4.	40S ribosomal protein S26; Belongs to the eukaryotic ribosomal protein eS26 family.	0.999
RPL4	RPS5	ENSECAP00000020849	ENSECAP00000013879	Ribosomal protein L4.	Ribosomal protein S5; Belongs to the universal ribosomal protein uS7 family.	0.999
RPL4	RPS8	ENSECAP00000020849	ENSECAP00000012814	Ribosomal protein L4.	40S ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family.	0.999
RPL4	RPS9	ENSECAP00000020849	ENSECAP00000017862	Ribosomal protein L4.	Ribosomal protein S9; Belongs to the universal ribosomal protein uS4 family.	0.999

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.968

expected number of edges:

11

PPI enrichment p-value:

3.84e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006525

Arginine metabolic process

11 of 34

2.23

8.23

2.82e-21

GO:0006526

Arginine biosynthetic process

9 of 17

2.45

8.04

4.90e-18

GO:0006591

Ornithine metabolic process

4 of 6

2.55

3.56

1.65e-07

GO:0042450

Arginine biosynthetic process via ornithine

2 of 2

2.72

1.57

0.0014

GO:0044205

De novo UMP biosynthetic process

2 of 7

2.18

1.12

0.0079

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0103045

Methione N-acyltransferase activity

2 of 2

2.72

0.93

0.0203

GO:0004088

Carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity

2 of 2

2.72

0.93

0.0203

GO:0004042

acetyl-CoA:L-glutamate N-acetyltransferase activity

2 of 2

2.72

0.93

0.0203

GO:0016774

Phosphotransferase activity, carboxyl group as acceptor

2 of 7

2.18

0.82

0.0303

GO:0016879

Ligase activity, forming carbon-nitrogen bonds

3 of 51

1.49

0.73

0.0303

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

11 of 1829

0.5

0.42

0.00052

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1505

Arginine biosynthesis, and Amino acid antiporter

9 of 15

2.5

8.22

4.37e-18

CL:1510

Arginine biosynthesis

6 of 6

2.72

6.12

1.70e-12

CL:1367

Cellular amino acid biosynthetic process, and Ribonucleoside monophosphate biosynthetic process

11 of 152

1.58

3.6

3.78e-15

CL:1525

Amino acid antiporter, and Arginine catabolic process to ornithine

2 of 5

2.33

1.03

0.0127

CL:1578

Pyrimidine biosynthesis, and Dihydroorotase, conserved site

2 of 6

2.25

0.99

0.0148

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pfn00220

Arginine biosynthesis

9 of 36

2.12

6.25

3.12e-16

pfn00250

Alanine, aspartate and glutamate metabolism

4 of 39

1.74

1.95

3.78e-05

pfn01230

Biosynthesis of amino acids

7 of 179

1.32

1.75

6.17e-07

pfn01210

2-Oxocarboxylic acid metabolism

4 of 51

1.62

1.75

6.84e-05

pfn01110

Biosynthesis of secondary metabolites

8 of 614

0.84

0.78

6.84e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005951

Carbamoyl-phosphate synthase complex

2 of 2

2.72

1.18

0.0073

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0055

Arginine biosynthesis

9 of 13

2.56

8.87

2.96e-19

KW-0963

Cytoplasm

8 of 311

1.13

1.38

8.14e-07

KW-0665

Pyrimidine biosynthesis

2 of 10

2.03

1.0

0.0124

KW-0436

Ligase

3 of 73

1.34

0.8

0.0152

KW-0808

Transferase

5 of 407

0.81

0.51

0.0216

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00696

Amino acid kinase family

3 of 6

2.42

1.85

0.00035

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036393

Acetylglutamate kinase-like superfamily

3 of 6

2.42

1.71

0.00065

IPR001048

Aspartate/glutamate/uridylate kinase

3 of 6

2.42

1.71

0.00065

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