node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ESR1 | ESR2 | ENSECAP00000020141 | ENSECAP00000022532 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Estrogen receptor 2. | 0.997 |
ESR1 | FOS | ENSECAP00000020141 | ENSECAP00000011892 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Fos proto-oncogene, AP-1 transcription factor subunit. | 0.984 |
ESR1 | JUN | ENSECAP00000020141 | ENSECAP00000021482 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. | 0.983 |
ESR1 | MED1 | ENSECAP00000020141 | ENSECAP00000007560 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.983 |
ESR1 | NCOA1 | ENSECAP00000020141 | ENSECAP00000038479 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Nuclear receptor coactivator. | 0.998 |
ESR1 | NCOA2 | ENSECAP00000020141 | ENSECAP00000023894 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Nuclear receptor coactivator. | 0.995 |
ESR1 | NCOA3 | ENSECAP00000020141 | ENSECAP00000044340 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Nuclear receptor coactivator. | 0.998 |
ESR1 | NCOR1 | ENSECAP00000020141 | ENSECAP00000045299 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Nuclear receptor corepressor 1. | 0.984 |
ESR1 | SP1 | ENSECAP00000020141 | ENSECAP00000038780 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Sp1 transcription factor. | 0.988 |
ESR1 | SRC | ENSECAP00000020141 | ENSECAP00000010024 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Tyrosine-protein kinase. | 0.998 |
ESR2 | ESR1 | ENSECAP00000022532 | ENSECAP00000020141 | Estrogen receptor 2. | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | 0.997 |
ESR2 | FOS | ENSECAP00000022532 | ENSECAP00000011892 | Estrogen receptor 2. | Fos proto-oncogene, AP-1 transcription factor subunit. | 0.969 |
ESR2 | JUN | ENSECAP00000022532 | ENSECAP00000021482 | Estrogen receptor 2. | Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. | 0.966 |
ESR2 | MED1 | ENSECAP00000022532 | ENSECAP00000007560 | Estrogen receptor 2. | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.974 |
ESR2 | NCOA1 | ENSECAP00000022532 | ENSECAP00000038479 | Estrogen receptor 2. | Nuclear receptor coactivator. | 0.986 |
ESR2 | NCOA2 | ENSECAP00000022532 | ENSECAP00000023894 | Estrogen receptor 2. | Nuclear receptor coactivator. | 0.960 |
ESR2 | NCOA3 | ENSECAP00000022532 | ENSECAP00000044340 | Estrogen receptor 2. | Nuclear receptor coactivator. | 0.982 |
ESR2 | NCOR1 | ENSECAP00000022532 | ENSECAP00000045299 | Estrogen receptor 2. | Nuclear receptor corepressor 1. | 0.963 |
ESR2 | SP1 | ENSECAP00000022532 | ENSECAP00000038780 | Estrogen receptor 2. | Sp1 transcription factor. | 0.973 |
ESR2 | SRC | ENSECAP00000022532 | ENSECAP00000010024 | Estrogen receptor 2. | Tyrosine-protein kinase. | 0.976 |