ID3 protein (Equus caballus) - STRING interaction network

Nodes:

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

ID3

Inhibitor of DNA binding 3, HLH protein. (227 aa)

Predicted Functional Partners:

TCF3

0.659

ST14

0.655

TRIML1

0.654

ID1

0.599

TRIML2

0.568

FRG1

0.516

FKBP4

0.515

CCNL1

0.489

GABRQ

0.488

PITHD1

0.487

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCNL1	ID3	ENSECAP00000006929	ENSECAP00000020735	Cyclin L1; Belongs to the cyclin family.	Inhibitor of DNA binding 3, HLH protein.	0.489
FKBP4	ID3	ENSECAP00000018238	ENSECAP00000020735	Peptidylprolyl isomerase.	Inhibitor of DNA binding 3, HLH protein.	0.515
FRG1	ID3	ENSECAP00000002829	ENSECAP00000020735	FSHD region gene 1.	Inhibitor of DNA binding 3, HLH protein.	0.516
FRG1	TRIML1	ENSECAP00000002829	ENSECAP00000009695	FSHD region gene 1.	Tripartite motif family like 1.	0.716
FRG1	TRIML2	ENSECAP00000002829	ENSECAP00000010177	FSHD region gene 1.	Tripartite motif family like 2.	0.672
GABRQ	ID3	ENSECAP00000036551	ENSECAP00000020735	Gamma-aminobutyric acid type A receptor theta subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	Inhibitor of DNA binding 3, HLH protein.	0.488
ID1	ID3	ENSECAP00000041465	ENSECAP00000020735	Inhibitor of DNA binding 1, HLH protein.	Inhibitor of DNA binding 3, HLH protein.	0.599
ID1	ST14	ENSECAP00000041465	ENSECAP00000005022	Inhibitor of DNA binding 1, HLH protein.	Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family.	0.490
ID1	TCF3	ENSECAP00000041465	ENSECAP00000036149	Inhibitor of DNA binding 1, HLH protein.	Transcription factor 3.	0.984
ID3	CCNL1	ENSECAP00000020735	ENSECAP00000006929	Inhibitor of DNA binding 3, HLH protein.	Cyclin L1; Belongs to the cyclin family.	0.489
ID3	FKBP4	ENSECAP00000020735	ENSECAP00000018238	Inhibitor of DNA binding 3, HLH protein.	Peptidylprolyl isomerase.	0.515
ID3	FRG1	ENSECAP00000020735	ENSECAP00000002829	Inhibitor of DNA binding 3, HLH protein.	FSHD region gene 1.	0.516
ID3	GABRQ	ENSECAP00000020735	ENSECAP00000036551	Inhibitor of DNA binding 3, HLH protein.	Gamma-aminobutyric acid type A receptor theta subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	0.488
ID3	ID1	ENSECAP00000020735	ENSECAP00000041465	Inhibitor of DNA binding 3, HLH protein.	Inhibitor of DNA binding 1, HLH protein.	0.599
ID3	PITHD1	ENSECAP00000020735	ENSECAP00000015093	Inhibitor of DNA binding 3, HLH protein.	PITH domain containing 1.	0.487
ID3	ST14	ENSECAP00000020735	ENSECAP00000005022	Inhibitor of DNA binding 3, HLH protein.	Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family.	0.655
ID3	TCF3	ENSECAP00000020735	ENSECAP00000036149	Inhibitor of DNA binding 3, HLH protein.	Transcription factor 3.	0.659
ID3	TRIML1	ENSECAP00000020735	ENSECAP00000009695	Inhibitor of DNA binding 3, HLH protein.	Tripartite motif family like 1.	0.654
ID3	TRIML2	ENSECAP00000020735	ENSECAP00000010177	Inhibitor of DNA binding 3, HLH protein.	Tripartite motif family like 2.	0.568
PITHD1	ID3	ENSECAP00000015093	ENSECAP00000020735	PITH domain containing 1.	Inhibitor of DNA binding 3, HLH protein.	0.487

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

14

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042176

Regulation of protein catabolic process

5 of 28

2.18

3.49

5.69e-08

GO:0010498

Proteasomal protein catabolic process

8 of 142

1.67

3.21

2.81e-10

GO:0051603

Proteolysis involved in protein catabolic process

10 of 235

1.55

3.09

5.48e-12

GO:0006511

Ubiquitin-dependent protein catabolic process

9 of 208

1.56

2.94

8.65e-11

GO:0043248

Proteasome assembly

4 of 19

2.25

2.88

1.98e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0036402

Proteasome-activating activity

3 of 6

2.62

2.04

0.00017

GO:0004298

Threonine-type endopeptidase activity

2 of 5

2.53

0.92

0.0213

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000502

Proteasome complex

11 of 35

2.42

9.97

1.08e-23

GO:0005838

Proteasome regulatory particle

9 of 20

2.58

9.13

8.60e-20

GO:0008541

Proteasome regulatory particle, lid subcomplex

5 of 10

2.62

4.98

2.59e-10

GO:0008540

Proteasome regulatory particle, base subcomplex

4 of 9

2.57

3.75

7.23e-08

GO:0019774

Proteasome core complex, beta-subunit complex

2 of 7

2.38

1.33

0.0035

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1460

Proteasome complex

11 of 33

2.45

10.08

1.23e-23

CL:1461

Proteasome complex

8 of 28

2.38

6.99

7.87e-16

CL:1463

Proteasome accessory complex

6 of 14

2.56

5.77

3.82e-12

CL:1516

Proteasome regulatory particle, lid subcomplex

3 of 5

2.7

2.67

1.17e-05

CL:1466

Proteasome accessory complex

3 of 9

2.45

2.33

4.15e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03050

Proteasome

11 of 40

2.36

9.72

6.99e-24

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1236978

Cross-presentation of soluble exogenous antigens (endosomes)

11 of 38

2.39

9.66

2.66e-23

MAP-1236975

Antigen processing-Cross presentation

11 of 39

2.37

9.6

2.66e-23

MAP-5689880

Ub-specific processing proteases

11 of 72

2.11

7.46

4.92e-21

MAP-5688426

Deubiquitination

11 of 101

1.96

6.29

1.20e-19

MAP-983169

Class I MHC mediated antigen processing & presentation

11 of 164

1.75

4.74

1.57e-17

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000502

Proteasome complex

11 of 81

2.06

6.92

5.10e-20

GOCC:0005838

Proteasome regulatory particle

4 of 16

2.32

3.06

1.03e-06

GOCC:0008540

Proteasome regulatory particle, base subcomplex

3 of 8

2.5

2.45

2.54e-05

GOCC:0019774

Proteasome core complex, beta-subunit complex

2 of 7

2.38

1.24

0.0051

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0647

Proteasome

5 of 22

2.28

3.83

1.62e-08

KW-0645

Protease

3 of 107

1.37

0.69

0.0312

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000717

Proteasome component (PCI) domain

5 of 17

2.39

3.68

5.95e-08

IPR036390

Winged helix DNA-binding domain superfamily

5 of 60

1.84

2.27

9.12e-06

IPR005937

26S proteasome regulatory subunit P45-like

3 of 6

2.62

2.17

9.68e-05

IPR003960

ATPase, AAA-type, conserved site

3 of 21

2.08

1.44

0.0017

IPR003959

ATPase, AAA-type, core

3 of 38

1.82

1.08

0.0072

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00088

Motif in proteasome subunits, Int-6, Nip-1 and TRIP-15

5 of 13

2.51

4.43

2.27e-09

SM00753

PCI/PINT associated module

2 of 4

2.62

1.37

0.0031

SM00382

ATPases associated with a variety of cellular activities

3 of 99

1.4

0.76

0.0218

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