STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IAPPIslet amyloid polypeptide. (119 aa)    
Predicted Functional Partners:
RAMP3
Uncharacterized protein.
    
 0.917
RAMP1
Receptor activity modifying protein 1.
    
 0.893
CALCR
Calcitonin receptor; Belongs to the G-protein coupled receptor 2 family.
    
 0.883
RAMP2
Receptor activity modifying protein 2.
    
 0.879
IDE
Insulin degrading enzyme.
    
 
 0.877
SNCA
Alpha-synuclein; Belongs to the synuclein family.
    
 0.834
INS
Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
   
 
 0.797
CALCRL
Calcitonin receptor like receptor; Belongs to the G-protein coupled receptor 2 family.
   
 0.782
PRNP
Major prion protein; Belongs to the prion family.
      
 0.766
APP
Amyloid beta precursor protein.
     
 0.691
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.