STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPINT1Serine peptidase inhibitor, Kunitz type 1. (863 aa)    
Predicted Functional Partners:
ST14
Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family.
   
 0.920
HGF
Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.
    
 0.904
TMPRSS11E
Transmembrane protease serine; Belongs to the peptidase S1 family.
   
 0.765
HGFAC
HGF activator.
    
 0.711
F12
Coagulation factor XII.
   
 0.698
MST1
Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily.
   
 0.678
CIAO3
Cytosolic iron-sulfur assembly component 3; Belongs to the NARF family.
   
  
 0.643
SEC24B
SEC24 homolog B, COPII coat complex component.
      
 0.601
KDF1
Keratinocyte differentiation factor 1.
   
  
 0.589
SH2B2
SH2B adaptor protein 2.
      
 0.562
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.