ITIH1 protein (Equus caballus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ITIH1

Inter-alpha-trypsin inhibitor heavy chain 1. (908 aa)

Predicted Functional Partners:

AMBP

0.848

FETUB

0.705

SERPINA10

0.691

APOH

0.652

C8A

0.643

AFM

0.579

SERPINC1

0.570

AHSG

0.566

APCS

0.563

SERPINA3

0.561

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFM	AMBP	ENSECAP00000046302	ENSECAP00000046787	Afamin.	Inter-alpha-trypsin inhibitor; This inhibitory fragment, released from native ITI after limited proteolysis with trypsin, contains two homologous domains. Whereas the second domain is a strong inhibitor of trypsin, the first domain interacts weakly with PMN-granulocytic elastase and not at all with pancreatic elastase.	0.517
AFM	APCS	ENSECAP00000046302	ENSECAP00000005925	Afamin.	Pentaxin.	0.745
AFM	APOH	ENSECAP00000046302	ENSECAP00000019727	Afamin.	Apolipoprotein H.	0.724
AFM	C8A	ENSECAP00000046302	ENSECAP00000050576	Afamin.	Complement C8 alpha chain.	0.650
AFM	FETUB	ENSECAP00000046302	ENSECAP00000052909	Afamin.	Fetuin B.	0.595
AFM	ITIH1	ENSECAP00000046302	ENSECAP00000022393	Afamin.	Inter-alpha-trypsin inhibitor heavy chain 1.	0.579
AHSG	AMBP	ENSECAP00000054154	ENSECAP00000046787	Alpha 2-HS glycoprotein.	Inter-alpha-trypsin inhibitor; This inhibitory fragment, released from native ITI after limited proteolysis with trypsin, contains two homologous domains. Whereas the second domain is a strong inhibitor of trypsin, the first domain interacts weakly with PMN-granulocytic elastase and not at all with pancreatic elastase.	0.886
AHSG	APOH	ENSECAP00000054154	ENSECAP00000019727	Alpha 2-HS glycoprotein.	Apolipoprotein H.	0.918
AHSG	FETUB	ENSECAP00000054154	ENSECAP00000052909	Alpha 2-HS glycoprotein.	Fetuin B.	0.735
AHSG	ITIH1	ENSECAP00000054154	ENSECAP00000022393	Alpha 2-HS glycoprotein.	Inter-alpha-trypsin inhibitor heavy chain 1.	0.566
AHSG	SERPINA10	ENSECAP00000054154	ENSECAP00000054967	Alpha 2-HS glycoprotein.	Serpin family A member 10; Belongs to the serpin family.	0.499
AHSG	SERPINA3	ENSECAP00000054154	ENSECAP00000011686	Alpha 2-HS glycoprotein.	Serpin family A member 3; Belongs to the serpin family.	0.460
AHSG	SERPINC1	ENSECAP00000054154	ENSECAP00000012335	Alpha 2-HS glycoprotein.	Serpin family C member 1; Belongs to the serpin family.	0.840
AMBP	AFM	ENSECAP00000046787	ENSECAP00000046302	Inter-alpha-trypsin inhibitor; This inhibitory fragment, released from native ITI after limited proteolysis with trypsin, contains two homologous domains. Whereas the second domain is a strong inhibitor of trypsin, the first domain interacts weakly with PMN-granulocytic elastase and not at all with pancreatic elastase.	Afamin.	0.517
AMBP	AHSG	ENSECAP00000046787	ENSECAP00000054154	Inter-alpha-trypsin inhibitor; This inhibitory fragment, released from native ITI after limited proteolysis with trypsin, contains two homologous domains. Whereas the second domain is a strong inhibitor of trypsin, the first domain interacts weakly with PMN-granulocytic elastase and not at all with pancreatic elastase.	Alpha 2-HS glycoprotein.	0.886
AMBP	APCS	ENSECAP00000046787	ENSECAP00000005925	Inter-alpha-trypsin inhibitor; This inhibitory fragment, released from native ITI after limited proteolysis with trypsin, contains two homologous domains. Whereas the second domain is a strong inhibitor of trypsin, the first domain interacts weakly with PMN-granulocytic elastase and not at all with pancreatic elastase.	Pentaxin.	0.446
AMBP	APOH	ENSECAP00000046787	ENSECAP00000019727	Inter-alpha-trypsin inhibitor; This inhibitory fragment, released from native ITI after limited proteolysis with trypsin, contains two homologous domains. Whereas the second domain is a strong inhibitor of trypsin, the first domain interacts weakly with PMN-granulocytic elastase and not at all with pancreatic elastase.	Apolipoprotein H.	0.886
AMBP	C8A	ENSECAP00000046787	ENSECAP00000050576	Inter-alpha-trypsin inhibitor; This inhibitory fragment, released from native ITI after limited proteolysis with trypsin, contains two homologous domains. Whereas the second domain is a strong inhibitor of trypsin, the first domain interacts weakly with PMN-granulocytic elastase and not at all with pancreatic elastase.	Complement C8 alpha chain.	0.585
AMBP	ITIH1	ENSECAP00000046787	ENSECAP00000022393	Inter-alpha-trypsin inhibitor; This inhibitory fragment, released from native ITI after limited proteolysis with trypsin, contains two homologous domains. Whereas the second domain is a strong inhibitor of trypsin, the first domain interacts weakly with PMN-granulocytic elastase and not at all with pancreatic elastase.	Inter-alpha-trypsin inhibitor heavy chain 1.	0.848
AMBP	SERPINA10	ENSECAP00000046787	ENSECAP00000054967	Inter-alpha-trypsin inhibitor; This inhibitory fragment, released from native ITI after limited proteolysis with trypsin, contains two homologous domains. Whereas the second domain is a strong inhibitor of trypsin, the first domain interacts weakly with PMN-granulocytic elastase and not at all with pancreatic elastase.	Serpin family A member 10; Belongs to the serpin family.	0.510