CCL5 protein (Equus caballus) - STRING interaction network

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CCL5

C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. (91 aa)

Predicted Functional Partners:

CCR5

0.999

CCR3

0.999

CCR1

0.999

CXCL10

0.997

CCL27

0.997

CCL28

0.995

CXCL11

0.995

CCL26

0.994

CCL24

0.994

CCL13

0.994

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCL13	CCL24	ENSECAP00000033652	ENSECAP00000028397	SCY domain-containing protein.	C-C motif chemokine ligand 24.	0.994
CCL13	CCL26	ENSECAP00000033652	ENSECAP00000020067	SCY domain-containing protein.	C-C motif chemokine.	0.993
CCL13	CCL27	ENSECAP00000033652	ENSECAP00000030099	SCY domain-containing protein.	C-C motif chemokine ligand 27.	0.951
CCL13	CCL28	ENSECAP00000033652	ENSECAP00000006560	SCY domain-containing protein.	C-C motif chemokine.	0.993
CCL13	CCL5	ENSECAP00000033652	ENSECAP00000022430	SCY domain-containing protein.	C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family.	0.994
CCL13	CCR1	ENSECAP00000033652	ENSECAP00000001353	SCY domain-containing protein.	C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.969
CCL13	CCR3	ENSECAP00000033652	ENSECAP00000001001	SCY domain-containing protein.	C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	0.971
CCL13	CCR5	ENSECAP00000033652	ENSECAP00000000806	SCY domain-containing protein.	Chemokine receptor 5/2 large transcript; Belongs to the G-protein coupled receptor 1 family.	0.687
CCL13	CXCL10	ENSECAP00000033652	ENSECAP00000011110	SCY domain-containing protein.	C-X-C motif chemokine.	0.966
CCL13	CXCL11	ENSECAP00000033652	ENSECAP00000010001	SCY domain-containing protein.	C-X-C motif chemokine.	0.967
CCL24	CCL13	ENSECAP00000028397	ENSECAP00000033652	C-C motif chemokine ligand 24.	SCY domain-containing protein.	0.994
CCL24	CCL26	ENSECAP00000028397	ENSECAP00000020067	C-C motif chemokine ligand 24.	C-C motif chemokine.	0.969
CCL24	CCL27	ENSECAP00000028397	ENSECAP00000030099	C-C motif chemokine ligand 24.	C-C motif chemokine ligand 27.	0.977
CCL24	CCL28	ENSECAP00000028397	ENSECAP00000006560	C-C motif chemokine ligand 24.	C-C motif chemokine.	0.940
CCL24	CCL5	ENSECAP00000028397	ENSECAP00000022430	C-C motif chemokine ligand 24.	C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family.	0.994
CCL24	CCR1	ENSECAP00000028397	ENSECAP00000001353	C-C motif chemokine ligand 24.	C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.875
CCL24	CCR3	ENSECAP00000028397	ENSECAP00000001001	C-C motif chemokine ligand 24.	C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	0.988
CCL24	CCR5	ENSECAP00000028397	ENSECAP00000000806	C-C motif chemokine ligand 24.	Chemokine receptor 5/2 large transcript; Belongs to the G-protein coupled receptor 1 family.	0.431
CCL24	CXCL10	ENSECAP00000028397	ENSECAP00000011110	C-C motif chemokine ligand 24.	C-X-C motif chemokine.	0.694
CCL24	CXCL11	ENSECAP00000028397	ENSECAP00000010001	C-C motif chemokine ligand 24.	C-X-C motif chemokine.	0.971

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