AFF3 protein (Equus caballus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

AFF3

AF4/FMR2 family member 3. (1251 aa)

Predicted Functional Partners:

ELL

0.757

ELL2

0.717

LOC100056183

0.717

EAF1

0.710

ELL3

0.709

CCNT1

0.707

CCNT2

0.701

UNC79

0.696

CDK9

0.693

ZFP2

0.687

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFF3	CCNT1	ENSECAP00000023235	ENSECAP00000013646	AF4/FMR2 family member 3.	Cyclin-T1; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (C- terminal domain) of the large subunit of RNA polymerase II (RNAP II) (By similarity). In case of equine infectious anemia virus (EIAV) infection, binds to the nuclear transcriptional activator Tat, increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Ta [...]	0.707
AFF3	CCNT2	ENSECAP00000023235	ENSECAP00000044676	AF4/FMR2 family member 3.	Cyclin T2; Belongs to the cyclin family.	0.701
AFF3	CDK9	ENSECAP00000023235	ENSECAP00000036625	AF4/FMR2 family member 3.	Cyclin dependent kinase 9; Belongs to the protein kinase superfamily.	0.693
AFF3	EAF1	ENSECAP00000023235	ENSECAP00000021849	AF4/FMR2 family member 3.	ELL associated factor 1.	0.710
AFF3	ELL	ENSECAP00000023235	ENSECAP00000031935	AF4/FMR2 family member 3.	Elongation factor for RNA polymerase II.	0.757
AFF3	ELL2	ENSECAP00000023235	ENSECAP00000020537	AF4/FMR2 family member 3.	Elongation factor for RNA polymerase II 2.	0.717
AFF3	ELL3	ENSECAP00000023235	ENSECAP00000013457	AF4/FMR2 family member 3.	Elongation factor for RNA polymerase II 3.	0.709
AFF3	LOC100056183	ENSECAP00000023235	ENSECAP00000023412	AF4/FMR2 family member 3.	ELL domain-containing protein.	0.717
AFF3	UNC79	ENSECAP00000023235	ENSECAP00000016218	AF4/FMR2 family member 3.	Unc-79 homolog, NALCN channel complex subunit.	0.696
AFF3	ZFP2	ENSECAP00000023235	ENSECAP00000003549	AF4/FMR2 family member 3.	ZFP2 zinc finger protein.	0.687
CCNT1	AFF3	ENSECAP00000013646	ENSECAP00000023235	Cyclin-T1; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (C- terminal domain) of the large subunit of RNA polymerase II (RNAP II) (By similarity). In case of equine infectious anemia virus (EIAV) infection, binds to the nuclear transcriptional activator Tat, increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Ta [...]	AF4/FMR2 family member 3.	0.707
CCNT1	CCNT2	ENSECAP00000013646	ENSECAP00000044676	Cyclin-T1; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (C- terminal domain) of the large subunit of RNA polymerase II (RNAP II) (By similarity). In case of equine infectious anemia virus (EIAV) infection, binds to the nuclear transcriptional activator Tat, increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Ta [...]	Cyclin T2; Belongs to the cyclin family.	0.955
CCNT1	CDK9	ENSECAP00000013646	ENSECAP00000036625	Cyclin-T1; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (C- terminal domain) of the large subunit of RNA polymerase II (RNAP II) (By similarity). In case of equine infectious anemia virus (EIAV) infection, binds to the nuclear transcriptional activator Tat, increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Ta [...]	Cyclin dependent kinase 9; Belongs to the protein kinase superfamily.	0.999
CCNT1	EAF1	ENSECAP00000013646	ENSECAP00000021849	Cyclin-T1; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (C- terminal domain) of the large subunit of RNA polymerase II (RNAP II) (By similarity). In case of equine infectious anemia virus (EIAV) infection, binds to the nuclear transcriptional activator Tat, increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Ta [...]	ELL associated factor 1.	0.823
CCNT1	ELL	ENSECAP00000013646	ENSECAP00000031935	Cyclin-T1; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (C- terminal domain) of the large subunit of RNA polymerase II (RNAP II) (By similarity). In case of equine infectious anemia virus (EIAV) infection, binds to the nuclear transcriptional activator Tat, increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Ta [...]	Elongation factor for RNA polymerase II.	0.945
CCNT1	ELL2	ENSECAP00000013646	ENSECAP00000020537	Cyclin-T1; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (C- terminal domain) of the large subunit of RNA polymerase II (RNAP II) (By similarity). In case of equine infectious anemia virus (EIAV) infection, binds to the nuclear transcriptional activator Tat, increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Ta [...]	Elongation factor for RNA polymerase II 2.	0.953
CCNT1	ELL3	ENSECAP00000013646	ENSECAP00000013457	Cyclin-T1; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (C- terminal domain) of the large subunit of RNA polymerase II (RNAP II) (By similarity). In case of equine infectious anemia virus (EIAV) infection, binds to the nuclear transcriptional activator Tat, increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Ta [...]	Elongation factor for RNA polymerase II 3.	0.874
CCNT1	LOC100056183	ENSECAP00000013646	ENSECAP00000023412	Cyclin-T1; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (C- terminal domain) of the large subunit of RNA polymerase II (RNAP II) (By similarity). In case of equine infectious anemia virus (EIAV) infection, binds to the nuclear transcriptional activator Tat, increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Ta [...]	ELL domain-containing protein.	0.806
CCNT2	AFF3	ENSECAP00000044676	ENSECAP00000023235	Cyclin T2; Belongs to the cyclin family.	AF4/FMR2 family member 3.	0.701
CCNT2	CCNT1	ENSECAP00000044676	ENSECAP00000013646	Cyclin T2; Belongs to the cyclin family.	Cyclin-T1; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (C- terminal domain) of the large subunit of RNA polymerase II (RNAP II) (By similarity). In case of equine infectious anemia virus (EIAV) infection, binds to the nuclear transcriptional activator Tat, increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Ta [...]	0.955