STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TCF7L2Transcription factor 7 like 2. (669 aa)    
Predicted Functional Partners:
CTNNB1
Beta catenin 1.
    
 0.999
NLK
Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
    
 0.991
LEF1
Lymphoid enhancer binding factor 1.
    
0.982
JUP
Junction plakoglobin.
    
 0.974
AXIN2
Axin 2.
   
 0.964
EP300
E1A binding protein p300.
   
 0.963
CREBBP
CREB binding protein.
   
 0.963
CTBP2
C-terminal binding protein 2.
   
 0.958
CTBP1
C-terminal binding protein 1.
    
 0.957
APC
APC regulator of WNT signaling pathway.
    
 0.955
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.