HES5 protein (Equus caballus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

HES5

Hes family bHLH transcription factor 5. (164 aa)

Predicted Functional Partners:

HES1

0.913

RBPJ

0.801

NOTCH3

0.790

JAG1

0.789

DLL1

0.785

NOTCH2

0.779

NOTCH1

0.745

MFNG

0.737

ID4

0.711

JAG2

0.687

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DLL1	HES1	ENSECAP00000012173	ENSECAP00000022927	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hes family bHLH transcription factor 1.	0.621
DLL1	HES5	ENSECAP00000012173	ENSECAP00000025391	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hes family bHLH transcription factor 5.	0.785
DLL1	JAG1	ENSECAP00000012173	ENSECAP00000011574	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.548
DLL1	JAG2	ENSECAP00000012173	ENSECAP00000041299	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.469
DLL1	MFNG	ENSECAP00000012173	ENSECAP00000015401	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase.	0.689
DLL1	NOTCH1	ENSECAP00000012173	ENSECAP00000020734	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1.	0.999
DLL1	NOTCH2	ENSECAP00000012173	ENSECAP00000045755	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 2.	0.993
DLL1	NOTCH3	ENSECAP00000012173	ENSECAP00000019330	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 3.	0.994
DLL1	RBPJ	ENSECAP00000012173	ENSECAP00000045337	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Recombination signal binding protein for immunoglobulin kappa J region.	0.857
HES1	DLL1	ENSECAP00000022927	ENSECAP00000012173	Hes family bHLH transcription factor 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.621
HES1	HES5	ENSECAP00000022927	ENSECAP00000025391	Hes family bHLH transcription factor 1.	Hes family bHLH transcription factor 5.	0.913
HES1	JAG1	ENSECAP00000022927	ENSECAP00000011574	Hes family bHLH transcription factor 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.710
HES1	JAG2	ENSECAP00000022927	ENSECAP00000041299	Hes family bHLH transcription factor 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.621
HES1	NOTCH1	ENSECAP00000022927	ENSECAP00000020734	Hes family bHLH transcription factor 1.	Notch receptor 1.	0.720
HES1	NOTCH2	ENSECAP00000022927	ENSECAP00000045755	Hes family bHLH transcription factor 1.	Notch receptor 2.	0.691
HES1	NOTCH3	ENSECAP00000022927	ENSECAP00000019330	Hes family bHLH transcription factor 1.	Notch receptor 3.	0.646
HES1	RBPJ	ENSECAP00000022927	ENSECAP00000045337	Hes family bHLH transcription factor 1.	Recombination signal binding protein for immunoglobulin kappa J region.	0.781
HES5	DLL1	ENSECAP00000025391	ENSECAP00000012173	Hes family bHLH transcription factor 5.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.785
HES5	HES1	ENSECAP00000025391	ENSECAP00000022927	Hes family bHLH transcription factor 5.	Hes family bHLH transcription factor 1.	0.913
HES5	ID4	ENSECAP00000025391	ENSECAP00000011106	Hes family bHLH transcription factor 5.	Inhibitor of DNA binding 4, HLH protein.	0.711