METTL15 protein (Equus caballus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

METTL15

Methyltransferase like 15. (483 aa)

Predicted Functional Partners:

MPV17L2

0.902

MAF1

0.854

DAP3

0.804

RBFA

0.803

MRPS9

0.754

MRPS12

0.741

MRPS10

0.741

MRPS6

0.737

MRPS15

0.713

MRPS11

0.712

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DAP3	METTL15	ENSECAP00000013976	ENSECAP00000026488	Death associated protein 3.	Methyltransferase like 15.	0.804
DAP3	MRPS10	ENSECAP00000013976	ENSECAP00000012945	Death associated protein 3.	Mitochondrial ribosomal protein S10.	0.999
DAP3	MRPS11	ENSECAP00000013976	ENSECAP00000005324	Death associated protein 3.	Mitochondrial ribosomal protein S11; Belongs to the universal ribosomal protein uS11 family.	0.998
DAP3	MRPS12	ENSECAP00000013976	ENSECAP00000011461	Death associated protein 3.	Mitochondrial ribosomal protein S12; Belongs to the universal ribosomal protein uS12 family.	0.998
DAP3	MRPS15	ENSECAP00000013976	ENSECAP00000000938	Death associated protein 3.	Mitochondrial ribosomal protein S15; Belongs to the universal ribosomal protein uS15 family.	0.999
DAP3	MRPS6	ENSECAP00000013976	ENSECAP00000010341	Death associated protein 3.	Mitochondrial ribosomal protein S6.	0.998
DAP3	MRPS9	ENSECAP00000013976	ENSECAP00000009224	Death associated protein 3.	Mitochondrial ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family.	0.999
DAP3	RBFA	ENSECAP00000013976	ENSECAP00000006256	Death associated protein 3.	Ribosome binding factor A.	0.703
MAF1	METTL15	ENSECAP00000004711	ENSECAP00000026488	Repressor of RNA polymerase III transcription MAF1; Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA. Belongs to the MAF1 family.	Methyltransferase like 15.	0.854
MAF1	MPV17L2	ENSECAP00000004711	ENSECAP00000018100	Repressor of RNA polymerase III transcription MAF1; Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA. Belongs to the MAF1 family.	MPV17 mitochondrial inner membrane protein like 2; Belongs to the peroxisomal membrane protein PXMP2/4 family.	0.854
METTL15	DAP3	ENSECAP00000026488	ENSECAP00000013976	Methyltransferase like 15.	Death associated protein 3.	0.804
METTL15	MAF1	ENSECAP00000026488	ENSECAP00000004711	Methyltransferase like 15.	Repressor of RNA polymerase III transcription MAF1; Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA. Belongs to the MAF1 family.	0.854
METTL15	MPV17L2	ENSECAP00000026488	ENSECAP00000018100	Methyltransferase like 15.	MPV17 mitochondrial inner membrane protein like 2; Belongs to the peroxisomal membrane protein PXMP2/4 family.	0.902
METTL15	MRPS10	ENSECAP00000026488	ENSECAP00000012945	Methyltransferase like 15.	Mitochondrial ribosomal protein S10.	0.741
METTL15	MRPS11	ENSECAP00000026488	ENSECAP00000005324	Methyltransferase like 15.	Mitochondrial ribosomal protein S11; Belongs to the universal ribosomal protein uS11 family.	0.712
METTL15	MRPS12	ENSECAP00000026488	ENSECAP00000011461	Methyltransferase like 15.	Mitochondrial ribosomal protein S12; Belongs to the universal ribosomal protein uS12 family.	0.741
METTL15	MRPS15	ENSECAP00000026488	ENSECAP00000000938	Methyltransferase like 15.	Mitochondrial ribosomal protein S15; Belongs to the universal ribosomal protein uS15 family.	0.713
METTL15	MRPS6	ENSECAP00000026488	ENSECAP00000010341	Methyltransferase like 15.	Mitochondrial ribosomal protein S6.	0.737
METTL15	MRPS9	ENSECAP00000026488	ENSECAP00000009224	Methyltransferase like 15.	Mitochondrial ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family.	0.754
METTL15	RBFA	ENSECAP00000026488	ENSECAP00000006256	Methyltransferase like 15.	Ribosome binding factor A.	0.803

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Network Stats

number of nodes:

11

number of edges:

32

average node degree:

5.82

avg. local clustering coefficient:

0.814

expected number of edges:

31

PPI enrichment p-value:

0.42

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009102

Biotin biosynthetic process

4 of 6

2.29

2.43

2.01e-05

GO:0072330

Monocarboxylic acid biosynthetic process

5 of 30

1.68

1.98

2.19e-05

GO:0046394

Carboxylic acid biosynthetic process

6 of 107

1.21

1.17

0.00022

GO:0044281

Small molecule metabolic process

7 of 429

0.67

0.46

0.0126

GO:0071704

Organic substance metabolic process

10 of 1181

0.39

0.28

0.0258

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36584052

(2022) The inside scoop: Comparative genomics of two intranuclear bacteria, Candidatus Berkiella cookevillensis and Candidatus Berkiella aquae.

4 of 114

1.01

0.78

0.0028

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1111

Biotin metabolic process

4 of 5

2.37

2.7

6.44e-06

CL:1034

Mixed, incl. Vitamin biosynthetic process, and Coenzyme A metabolic process

5 of 45

1.51

1.59

9.73e-05

CL:842

Small molecule biosynthetic process, and Nucleotide biosynthetic process

6 of 141

1.09

0.97

0.00055

CL:1311

Phosphopantetheine, and Fatty acid synthase activity

2 of 5

2.06

0.85

0.0254

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00780

Biotin metabolism

5 of 26

1.75

2.32

3.19e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0093

Biotin biosynthesis

2 of 3

2.29

0.9

0.0221

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