STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GDF15Growth differentiation factor 15. (300 aa)    
Predicted Functional Partners:
TGFBR2
Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
   
 0.935
GFRAL
GDNF family receptor alpha like.
   
 
 0.897
RET
Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.
    
 
 0.720
FGF21
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
   
  
 0.669
WFIKKN1
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1.
   
 
 0.589
ACOT13
Acyl-CoA thioesterase 13.
      
 0.545
CCNJ
Cyclin J; Belongs to the cyclin family.
   
  
 0.525
AKAP7
A-kinase anchoring protein 7.
   
  
 0.520
BTBD9
BTB domain containing 9.
      
 0.505
KCNQ5
Potassium voltage-gated channel subfamily Q member 5.
   
  
 0.503
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.