STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC100054462Histone domain-containing protein. (444 aa)    
Predicted Functional Partners:
LOC102148494
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
 
 
 0.923
LOC100054332
Histone H4.
 
 
 0.923
LOC100630823
Histone H4.
 
 
 0.923
KDM6A
Lysine demethylase 6A.
   
 0.915
KDM1A
Lysine demethylase 1A.
   
 0.893
WDR5
WD repeat domain 5.
   
 0.883
H2AZ1
Histone H2A; Belongs to the histone H2A family.
   
 0.830
ATRX
ATRX chromatin remodeler.
    
 0.811
H2AX
Histone H2A; Belongs to the histone H2A family.
 
 
 0.810
KDM6B
Lysine demethylase 6B.
   
 0.787
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.