STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IDH3GIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (399 aa)    
Predicted Functional Partners:
IDH3A
Isocitrate dehydrogenase [NAD] subunit, mitochondrial.
  
0.998
IDH3B
Isocitrate dehydrogenase [NAD] subunit, mitochondrial.
  
0.994
DLST
Dihydrolipoamide S-succinyltransferase.
   
 0.918
ACO2
Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.
  
 0.900
OGDH
Oxoglutarate dehydrogenase.
  
 0.834
IDH2
Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.
  
 
 0.832
HMGCLL1
3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1.
  
 0.825
HMGCL
3-hydroxy-3-methylglutaryl-CoA lyase.
  
 0.825
SUCLA2
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 
 
 0.810
DLD
Dihydrolipoyl dehydrogenase.
  
 0.808
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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