LRP12 protein (Equus caballus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

LRP12

LDL receptor related protein 12. (858 aa)

Predicted Functional Partners:

GIPC1

0.687

SYDE2

0.654

ITSN2

0.615

LRPAP1

0.587

GGA2

0.572

GSK3B

0.560

GGA1

0.550

FZD8

0.501

RELN

0.492

ELP4

0.487

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ELP4	LRP12	ENSECAP00000052740	ENSECAP00000031385	Elongator acetyltransferase complex subunit 4.	LDL receptor related protein 12.	0.487
ELP4	SYDE2	ENSECAP00000052740	ENSECAP00000022702	Elongator acetyltransferase complex subunit 4.	Synapse defective Rho GTPase homolog 2.	0.931
FZD8	GSK3B	ENSECAP00000037496	ENSECAP00000022500	Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.545
FZD8	ITSN2	ENSECAP00000037496	ENSECAP00000023079	Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family.	Intersectin 2.	0.562
FZD8	LRP12	ENSECAP00000037496	ENSECAP00000031385	Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family.	LDL receptor related protein 12.	0.501
GGA1	GGA2	ENSECAP00000027939	ENSECAP00000017889	Golgi associated, gamma adaptin ear containing, ARF binding protein 1.	Golgi associated, gamma adaptin ear containing, ARF binding protein 2.	0.965
GGA1	LRP12	ENSECAP00000027939	ENSECAP00000031385	Golgi associated, gamma adaptin ear containing, ARF binding protein 1.	LDL receptor related protein 12.	0.550
GGA2	GGA1	ENSECAP00000017889	ENSECAP00000027939	Golgi associated, gamma adaptin ear containing, ARF binding protein 2.	Golgi associated, gamma adaptin ear containing, ARF binding protein 1.	0.965
GGA2	LRP12	ENSECAP00000017889	ENSECAP00000031385	Golgi associated, gamma adaptin ear containing, ARF binding protein 2.	LDL receptor related protein 12.	0.572
GIPC1	LRP12	ENSECAP00000044167	ENSECAP00000031385	GIPC PDZ domain containing family member 1.	LDL receptor related protein 12.	0.687
GSK3B	FZD8	ENSECAP00000022500	ENSECAP00000037496	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family.	0.545
GSK3B	ITSN2	ENSECAP00000022500	ENSECAP00000023079	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	Intersectin 2.	0.490
GSK3B	LRP12	ENSECAP00000022500	ENSECAP00000031385	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	LDL receptor related protein 12.	0.560
ITSN2	FZD8	ENSECAP00000023079	ENSECAP00000037496	Intersectin 2.	Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family.	0.562
ITSN2	GSK3B	ENSECAP00000023079	ENSECAP00000022500	Intersectin 2.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.490
ITSN2	LRP12	ENSECAP00000023079	ENSECAP00000031385	Intersectin 2.	LDL receptor related protein 12.	0.615
LRP12	ELP4	ENSECAP00000031385	ENSECAP00000052740	LDL receptor related protein 12.	Elongator acetyltransferase complex subunit 4.	0.487
LRP12	FZD8	ENSECAP00000031385	ENSECAP00000037496	LDL receptor related protein 12.	Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family.	0.501
LRP12	GGA1	ENSECAP00000031385	ENSECAP00000027939	LDL receptor related protein 12.	Golgi associated, gamma adaptin ear containing, ARF binding protein 1.	0.550
LRP12	GGA2	ENSECAP00000031385	ENSECAP00000017889	LDL receptor related protein 12.	Golgi associated, gamma adaptin ear containing, ARF binding protein 2.	0.572