node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADGRL1 | LOC111771935 | ENSECAP00000041821 | ENSECAP00000033420 | Adhesion G protein-coupled receptor L1; Belongs to the G-protein coupled receptor 2 family. | Toll-like receptor 4. | 0.579 |
ADGRL1 | LOC111772122 | ENSECAP00000041821 | ENSECAP00000031530 | Adhesion G protein-coupled receptor L1; Belongs to the G-protein coupled receptor 2 family. | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | 0.579 |
ADGRL1 | TLR2 | ENSECAP00000041821 | ENSECAP00000015544 | Adhesion G protein-coupled receptor L1; Belongs to the G-protein coupled receptor 2 family. | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] | 0.579 |
ADGRL1 | TLR4 | ENSECAP00000041821 | ENSECAP00000008292 | Adhesion G protein-coupled receptor L1; Belongs to the G-protein coupled receptor 2 family. | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] | 0.579 |
ADGRL2 | LOC111771935 | ENSECAP00000048035 | ENSECAP00000033420 | Adhesion G protein-coupled receptor L2; Belongs to the G-protein coupled receptor 2 family. | Toll-like receptor 4. | 0.579 |
ADGRL2 | LOC111772122 | ENSECAP00000048035 | ENSECAP00000031530 | Adhesion G protein-coupled receptor L2; Belongs to the G-protein coupled receptor 2 family. | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | 0.579 |
ADGRL2 | TLR2 | ENSECAP00000048035 | ENSECAP00000015544 | Adhesion G protein-coupled receptor L2; Belongs to the G-protein coupled receptor 2 family. | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] | 0.579 |
ADGRL2 | TLR4 | ENSECAP00000048035 | ENSECAP00000008292 | Adhesion G protein-coupled receptor L2; Belongs to the G-protein coupled receptor 2 family. | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] | 0.580 |
ADGRL3 | LOC111771935 | ENSECAP00000028710 | ENSECAP00000033420 | Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family. | Toll-like receptor 4. | 0.579 |
ADGRL3 | LOC111772122 | ENSECAP00000028710 | ENSECAP00000031530 | Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family. | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | 0.579 |
ADGRL3 | TLR2 | ENSECAP00000028710 | ENSECAP00000015544 | Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family. | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] | 0.579 |
ADGRL3 | TLR4 | ENSECAP00000028710 | ENSECAP00000008292 | Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family. | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] | 0.579 |
LOC111767791 | LOC111771935 | ENSECAP00000001239 | ENSECAP00000033420 | CD14 molecule. | Toll-like receptor 4. | 0.873 |
LOC111767791 | LOC111772122 | ENSECAP00000001239 | ENSECAP00000031530 | CD14 molecule. | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | 0.655 |
LOC111767791 | LY96 | ENSECAP00000001239 | ENSECAP00000015094 | CD14 molecule. | Lymphocyte antigen 96. | 0.919 |
LOC111767791 | TLR2 | ENSECAP00000001239 | ENSECAP00000015544 | CD14 molecule. | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] | 0.498 |
LOC111767791 | TLR4 | ENSECAP00000001239 | ENSECAP00000008292 | CD14 molecule. | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] | 0.873 |
LOC111771935 | ADGRL1 | ENSECAP00000033420 | ENSECAP00000041821 | Toll-like receptor 4. | Adhesion G protein-coupled receptor L1; Belongs to the G-protein coupled receptor 2 family. | 0.579 |
LOC111771935 | ADGRL2 | ENSECAP00000033420 | ENSECAP00000048035 | Toll-like receptor 4. | Adhesion G protein-coupled receptor L2; Belongs to the G-protein coupled receptor 2 family. | 0.579 |
LOC111771935 | ADGRL3 | ENSECAP00000033420 | ENSECAP00000028710 | Toll-like receptor 4. | Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family. | 0.579 |