ENSECAP00000031719 protein (Equus caballus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

ENSECAP00000031719

Uncharacterized protein. (438 aa)

Predicted Functional Partners:

F6THK5_HORSE

0.604

RHOB

0.604

RHOJ

0.604

F6SXQ9_HORSE

0.604

RHOU

0.604

RAC3

0.604

RND2

0.604

RND1

0.604

RND3

0.604

RHOV

0.604

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSECAP00000031719	F6SXQ9_HORSE	ENSECAP00000031719	ENSECAP00000003324	Uncharacterized protein.	Uncharacterized protein.	0.604
ENSECAP00000031719	F6THK5_HORSE	ENSECAP00000031719	ENSECAP00000001614	Uncharacterized protein.	Uncharacterized protein.	0.604
ENSECAP00000031719	RAC3	ENSECAP00000031719	ENSECAP00000011876	Uncharacterized protein.	Rac family small GTPase 3.	0.604
ENSECAP00000031719	RHOB	ENSECAP00000031719	ENSECAP00000001782	Uncharacterized protein.	Ras homolog family member B.	0.604
ENSECAP00000031719	RHOJ	ENSECAP00000031719	ENSECAP00000002569	Uncharacterized protein.	Ras homolog family member J.	0.604
ENSECAP00000031719	RHOU	ENSECAP00000031719	ENSECAP00000005644	Uncharacterized protein.	Ras homolog family member U.	0.604
ENSECAP00000031719	RHOV	ENSECAP00000031719	ENSECAP00000019187	Uncharacterized protein.	Ras homolog family member V.	0.604
ENSECAP00000031719	RND1	ENSECAP00000031719	ENSECAP00000018486	Uncharacterized protein.	Rho family GTPase 1.	0.604
ENSECAP00000031719	RND2	ENSECAP00000031719	ENSECAP00000012507	Uncharacterized protein.	Rho family GTPase 2.	0.604
ENSECAP00000031719	RND3	ENSECAP00000031719	ENSECAP00000018838	Uncharacterized protein.	Rho family GTPase 3.	0.604
F6SXQ9_HORSE	ENSECAP00000031719	ENSECAP00000003324	ENSECAP00000031719	Uncharacterized protein.	Uncharacterized protein.	0.604
F6SXQ9_HORSE	F6THK5_HORSE	ENSECAP00000003324	ENSECAP00000001614	Uncharacterized protein.	Uncharacterized protein.	0.411
F6SXQ9_HORSE	RAC3	ENSECAP00000003324	ENSECAP00000011876	Uncharacterized protein.	Rac family small GTPase 3.	0.618
F6SXQ9_HORSE	RHOB	ENSECAP00000003324	ENSECAP00000001782	Uncharacterized protein.	Ras homolog family member B.	0.475
F6SXQ9_HORSE	RND1	ENSECAP00000003324	ENSECAP00000018486	Uncharacterized protein.	Rho family GTPase 1.	0.454
F6SXQ9_HORSE	RND3	ENSECAP00000003324	ENSECAP00000018838	Uncharacterized protein.	Rho family GTPase 3.	0.443
F6THK5_HORSE	ENSECAP00000031719	ENSECAP00000001614	ENSECAP00000031719	Uncharacterized protein.	Uncharacterized protein.	0.604
F6THK5_HORSE	F6SXQ9_HORSE	ENSECAP00000001614	ENSECAP00000003324	Uncharacterized protein.	Uncharacterized protein.	0.411
F6THK5_HORSE	RAC3	ENSECAP00000001614	ENSECAP00000011876	Uncharacterized protein.	Rac family small GTPase 3.	0.419
F6THK5_HORSE	RHOB	ENSECAP00000001614	ENSECAP00000001782	Uncharacterized protein.	Ras homolog family member B.	0.453

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

49

average node degree:

8.91

avg. local clustering coefficient:

0.927

expected number of edges:

12

PPI enrichment p-value:

4.11e-15

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015813

L-glutamate transmembrane transport

8 of 34

2.68

8.21

4.55e-17

GO:0015804

Neutral amino acid transport

8 of 64

2.41

7.02

1.02e-15

GO:0098657

Import into cell

10 of 158

2.11

6.5

3.39e-17

GO:0140009

L-aspartate import across plasma membrane

5 of 8

3.11

6.13

5.03e-12

GO:0098712

L-glutamate import across plasma membrane

5 of 12

2.93

5.77

1.70e-11

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015501

Glutamate:sodium symporter activity

7 of 14

3.01

8.7

3.97e-17

GO:0015370

Solute:sodium symporter activity

10 of 102

2.3

8.03

1.67e-19

GO:0005313

L-glutamate transmembrane transporter activity

7 of 25

2.76

7.79

6.81e-16

GO:0015175

Neutral amino acid transmembrane transporter activity

7 of 62

2.37

6.14

9.50e-14

GO:0008509

Anion transmembrane transporter activity

10 of 358

1.76

4.43

2.94e-15

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045202

Synapse

10 of 1052

1.29

2.02

6.44e-10

GO:0098793

Presynapse

5 of 385

1.43

1.51

8.55e-05

GO:0005887

Integral component of plasma membrane

9 of 1342

1.14

1.44

1.90e-07

GO:0032809

Neuronal cell body membrane

2 of 23

2.25

1.19

0.0060

GO:0045121

Membrane raft

3 of 138

1.65

1.13

0.0042

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:39553

Glutamate:sodium symporter activity, and Dopamine:sodium symporter activity

10 of 20

3.01

12.83

1.55e-25

CL:39555

Glutamate:sodium symporter activity, and Dopamine:sodium symporter activity

8 of 15

3.04

10.29

3.08e-20

CL:39557

Glutamate:sodium symporter activity, and Dopamine:sodium symporter activity

7 of 10

3.16

9.3

4.84e-18

CL:39559

D-amino acid transport, and Dopamine:sodium symporter activity

3 of 5

3.09

3.14

1.97e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

7 of 47

2.49

6.68

1.89e-14

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-210500

Glutamate Neurotransmitter Release Cycle

7 of 52

2.44

6.21

1.54e-13

MAP-112310

Neurotransmitter release cycle

7 of 110

2.12

4.8

1.11e-11

MAP-425393

Transport of inorganic cations/anions and amino acids/oligopeptides

8 of 188

1.94

4.51

2.46e-12

MAP-425407

SLC-mediated transmembrane transport

10 of 424

1.69

3.85

1.10e-13

MAP-112315

Transmission across Chemical Synapses

8 of 444

1.57

2.79

1.04e-09

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001489

Whole body

11 of 11939

0.28

0.25

0.0081

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005887

Integral component of plasma membrane

5 of 403

1.41

1.19

0.0012

GOCC:0032809

Neuronal cell body membrane

2 of 17

2.38

1.15

0.0077

GOCC:0005886

Plasma membrane

8 of 2464

0.82

0.67

0.0012

GOCC:0016020

Membrane

10 of 4744

0.64

0.51

0.0012

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0769

Symport

10 of 60

2.53

10.07

1.58e-22

KW-1133

Transmembrane helix

11 of 6003

0.58

0.5

5.45e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00375

Sodium:dicarboxylate symporter family

7 of 17

2.93

8.11

3.96e-16

PF00209

Sodium:neurotransmitter symporter family

3 of 44

2.15

1.49

0.0014

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